CAJ | 학술논문

目的：探讨CX3CL1、CX3CR1在胃癌组织及癌旁组织中的表达及其意义。方法：收集30例胃癌患者手术切除的癌组织及对应癌旁组织，用 ELISA和 western blot法分别检测标本中CX3CL1及CX3CR1的蛋白水平。结果：ELISA法显示CX3CL1在胃癌组织中的表达水平高于对应癌旁组织（P＜0．05），western blot法显示CX3CR1蛋白在胃癌组织中的表达水平高于对应癌旁组织（P＜0．05）。结论：胃癌组织中CX3CL1、CX3CR1的高表达可能与胃癌的发生发展密切相关。
목적：탐토CX3CL1、CX3CR1재위암조직급암방조직중적표체급기의의。방법：수집30례위암환자수술절제적암조직급대응암방조직，용 ELISA화 western blot법분별검측표본중CX3CL1급CX3CR1적단백수평。결과：ELISA법현시CX3CL1재위암조직중적표체수평고우대응암방조직（P＜0．05），western blot법현시CX3CR1단백재위암조직중적표체수평고우대응암방조직（P＜0．05）。결론：위암조직중CX3CL1、CX3CR1적고표체가능여위암적발생발전밀절상관。
Objective :To detect the expression of CX3CL1 and CX3CR1 in human gastric cancer and its adjacent tis-sue .Methods :The primary tumor tissues and matching adjacent non-cancerous tissues from 30 gastric cancer patients were collected .CX3CL1 protein levels were detected by ELISA ,and CX3CR1 protein levels were detected by western blot analysis from all the specimens .Results:ELISA demonstrated that the mean level of CX3CL1 in gastric cancer tis-sues was higher than that in matching adjacent non-cancerous tissues (P<0 .05) .Western blot analysis demonstrated that the mean expression level of CX3CR1 protein in gastric cancer tissues was higher than that in matching adjacent non-cancerous tissues (P<0 .05) .Conclusion:High expression of CX3CL1 and CX3CR1 may plays a critical role in the development of gastric cancer .