CAJ | 학술논문

目的：探讨血清1，5-脱水葡糖醇（1，5-AG）在糖尿病血管损伤期的诊断价值。方法将133例患者分为糖尿病组81例（包括单纯2型糖尿病25例、2型糖尿病视网膜病变44例和糖尿病肾脏病变12例）和非糖尿病组52例（包括视网膜病变28例和肾脏病变24例），测定血清葡萄糖和血清1，5-脱水葡糖醇。绘制受试者工作特征（ROC）曲线，计算血糖（Glu）和1，5-AG诊断糖尿病血管损伤的敏感性、特异性、约登指数和曲线下面积。结果糖尿病组血清Glu 水平明显高于非糖尿病组（P＜0．05），糖尿病组血清1，5-AG水平明显低于非糖尿病组（P＜0．05）。ROC 曲线分析结果显示，Glu 诊断糖尿病血管损伤的最佳临界点为5．1450 mmol/L，敏感性为88．9％，特异性为90．4％，约登指数为0．7927，ROC 曲线下面积为0．9330。血清1，5-AG诊断糖尿病血管损伤的最佳临界点为98．6500μmol/L，敏感性为92．6％，特异性为96．2％，约登指数为0．8875，ROC 曲线下面积为0．9800。结论血清1，5-AG对糖尿病血管损伤的诊断性能优于Glu，具有重要的临床意义。
목적：탐토혈청1，5-탈수포당순（1，5-AG）재당뇨병혈관손상기적진단개치。방법장133례환자분위당뇨병조81례（포괄단순2형당뇨병25례、2형당뇨병시망막병변44례화당뇨병신장병변12례）화비당뇨병조52례（포괄시망막병변28례화신장병변24례），측정혈청포도당화혈청1，5-탈수포당순。회제수시자공작특정（ROC）곡선，계산혈당（Glu）화1，5-AG진단당뇨병혈관손상적민감성、특이성、약등지수화곡선하면적。결과당뇨병조혈청Glu 수평명현고우비당뇨병조（P＜0．05），당뇨병조혈청1，5-AG수평명현저우비당뇨병조（P＜0．05）。ROC 곡선분석결과현시，Glu 진단당뇨병혈관손상적최가림계점위5．1450 mmol/L，민감성위88．9％，특이성위90．4％，약등지수위0．7927，ROC 곡선하면적위0．9330。혈청1，5-AG진단당뇨병혈관손상적최가림계점위98．6500μmol/L，민감성위92．6％，특이성위96．2％，약등지수위0．8875，ROC 곡선하면적위0．9800。결론혈청1，5-AG대당뇨병혈관손상적진단성능우우Glu，구유중요적림상의의。
Objective To investigate the diagnosis significance of serum 1 ,5-anhydroglucitol(1 ,5-AG)for diabetes mellitus with vascular injury.Methods A total of 133 patients were classified into diabetes mellitus(DM)group(81 cases)and non-DM group (52 cases).DM group included type 2 diabetes mellitus(25 cases),diabetic retinopathy(44 cases)and diabetic nephropathy(12 ca-ses),while non-DM group included retinopathy(28 cases)and nephropathy(24 cases).Receiver operating characteristic(ROC) curve was set up,and the sensitivity,specificity,Youden index and area under the curve(AUC)were analyzed for glucose(Glu)and 1,5-AG.Results Serum Glu level in DM group was significantly higher than that in non-DM group(P<0.05)and 1,5-AG level in DM group was significantly lower than that in non-DM group(P<0.05).According to ROC curve,it approved that the best cut-off point of Glu and 1,5-AG might be 5.145 0 mmol/L and 98.650 0μmol/L respectively.It was figured out that the sensitivities of Glu and 1,5-AG were respectively 88.9% and 92.6%,the specificities were 90.4% and 96.2%,the Youden indexes were 0.792 7 and 0.887 5,the ROC AUC were 0.933 0 and 0.980 0.Conclusion Serum 1,5-AG has clinical significance in vascular injury of dia-betes mellitus diagnosis,and is a better marker than Glu.