CAJ | 학술논문

目的：对广州地区中晚期妊娠妇女抗凝血酶Ⅲ（AT-Ⅲ）参考值范围的调查，初步探讨AT-Ⅲ检测在妊娠妇女中的应用价值。方法选取健康妊娠妇女250例及同期体检的健康非妊娠妇女118例，将健康妊娠妇女按孕周分组：孕周14～27周组设为中孕组，共124例，＞27周组设为！孕组，共126例。将上述各组按年龄再分为小于29岁组和大于或等于29岁组。收集所有入组人员抗凝静脉血1．8 mL，检测其血浆AT-Ⅲ水平，调查其相应的参考值范围。结果中孕组、晚孕组及健康对照组血浆AT-Ⅲ水平分别为99．0％（68．1％～117．0％）、92．0％（71．1％～112．0％）、103％（76．0％～127．8％），差异有统计学意义（P＜0．05）。＜29岁的中孕组、晚孕组及健康对照组血浆 AT-Ⅲ水平分别为96．85％（71．20％～116．85％）、93．60％（70．53％～136．48％）、103．75％（80．68％～139．48％），差异有统计学意义（P＜0．05）；≥29岁的中孕组、晚孕组及健康对照组血浆AT-Ⅲ水平分别为95．47％（77．40％～113．54％）、92．40％（69．20％～113．00％）、102．08％（75．20％～123．80％），差异有统计学意义（P＜0．05）。妊娠妇女AT-Ⅲ水平在不同孕期组间差异有统计学意义（P＜0．05），应制订不同的参考范围，而同一孕期内不同年龄段妊娠妇女AT-Ⅲ水平差异无统计学意义（P＞0．05），制订参考范围时可不考虑年龄因素。结论该研究为广州地区中晚期妊娠妇女人群AT-Ⅲ的参考值范围制订提供了一定的参考依据。
목적：대엄주지구중만기임신부녀항응혈매Ⅲ（AT-Ⅲ）삼고치범위적조사，초보탐토AT-Ⅲ검측재임신부녀중적응용개치。방법선취건강임신부녀250례급동기체검적건강비임신부녀118례，장건강임신부녀안잉주분조：잉주14～27주조설위중잉조，공124례，＞27주조설위！잉조，공126례。장상술각조안년령재분위소우29세조화대우혹등우29세조。수집소유입조인원항응정맥혈1．8 mL，검측기혈장AT-Ⅲ수평，조사기상응적삼고치범위。결과중잉조、만잉조급건강대조조혈장AT-Ⅲ수평분별위99．0％（68．1％～117．0％）、92．0％（71．1％～112．0％）、103％（76．0％～127．8％），차이유통계학의의（P＜0．05）。＜29세적중잉조、만잉조급건강대조조혈장 AT-Ⅲ수평분별위96．85％（71．20％～116．85％）、93．60％（70．53％～136．48％）、103．75％（80．68％～139．48％），차이유통계학의의（P＜0．05）；≥29세적중잉조、만잉조급건강대조조혈장AT-Ⅲ수평분별위95．47％（77．40％～113．54％）、92．40％（69．20％～113．00％）、102．08％（75．20％～123．80％），차이유통계학의의（P＜0．05）。임신부녀AT-Ⅲ수평재불동잉기조간차이유통계학의의（P＜0．05），응제정불동적삼고범위，이동일잉기내불동년령단임신부녀AT-Ⅲ수평차이무통계학의의（P＞0．05），제정삼고범위시가불고필년령인소。결론해연구위엄주지구중만기임신부녀인군AT-Ⅲ적삼고치범위제정제공료일정적삼고의거。
Objective To disscuss the significance of detection of plasma antithrombin-Ⅲ(AT-Ⅲ)in pregnant women,through investigating the reference value ranges for AT-Ⅲ of women in middle term and late pregnancy in Guangzhou.Methods 250 healthy pregnant women and 118 healthy non-pregnant women(control group)were selected as subjects.According the gestation-al weeks,250 healthy pregnant women were divided into two groups:second trimester group(124 cases,14-27 weeks gestation) and third trimester group (126 cases,>27 weeks gestation).The two experimental groups were divided into two age groups:<29 age group and ≥29 age group.1.8 mL anticoagulant venous blood was collected from each subjects and used for the detection of AT-Ⅲ,and the reference value ranges were investigated.Results The levels of AT-Ⅲ in second trimester group,third trimester group and control group were 99.0%(68.1%-117.0%),92.0%(71.1%-112.0%)and 103%(76.0%-127.8%),with signifi-cant difference(P<0.05).The AT-Ⅲ levels of women under-29-years old in second trimester group,third trimester group and control group were 96.85%(71.20%-116.85%),93.60%(70.53%-136.48%)and 103.75%(80.68%-139.48%),with sig-nificant difference(P<0.05).Meanwhile,the AT-Ⅲ levels of women aged 29 years and above in second trimester group,third tri-mester group and control group were 95.47%(77.40%-113.54%),92.40%(69.20%-113.00%)and 102.08%(75.20%-123.80%),also with significant difference(P<0.05).The AT-Ⅲ levels were significantly different between two trismester groups (P<0.05),but were not different among age groups(P>0.05).So the gestational factors should be considered when make the AT-Ⅲ reference range,and regardless of age.Conclusion This study provides reference basis for the establishment of AT-Ⅲ refer-ence values of women in second and third trismesters in Guangzhou.