CAJ | 학술논문

目的：探讨血清肿瘤标志物糖类抗原19-9（CA19-9）在不同类型肿瘤患者及健康人血清中的检测水平，系统性地评价其在肿瘤中的临床应用价值。方法采用化学发光免疫蛋白定量分析法对767例肿瘤患者（病例组）及288例同期健康体检个体（对照组）进行血清CA19-9检测。结果在对照组中，CA19-9普遍具有较低的表达水平，均值为（14．2±8．9）IU/mL，但是在不同系统的恶性肿瘤中均发现血清CA19-9水平显著上升，在同一系统不同类型的恶性肿瘤当中，血清CA19-9水平也各有差异，呈现出表达水平的异质性。结论 CA19-9在食管癌、肝癌、胰腺癌、胆囊癌等恶性肿瘤中呈高水平表达，提示 CA19-9在临床检测中具有较高的应用价值，但其在一些良性肿瘤和炎症病变中的高表达也提示临床在CA19-9的应用中仍需注意对相关良性肿瘤的鉴别分析。
목적：탐토혈청종류표지물당류항원19-9（CA19-9）재불동류형종류환자급건강인혈청중적검측수평，계통성지평개기재종류중적림상응용개치。방법채용화학발광면역단백정량분석법대767례종류환자（병례조）급288례동기건강체검개체（대조조）진행혈청CA19-9검측。결과재대조조중，CA19-9보편구유교저적표체수평，균치위（14．2±8．9）IU/mL，단시재불동계통적악성종류중균발현혈청CA19-9수평현저상승，재동일계통불동류형적악성종류당중，혈청CA19-9수평야각유차이，정현출표체수평적이질성。결론 CA19-9재식관암、간암、이선암、담낭암등악성종류중정고수평표체，제시 CA19-9재림상검측중구유교고적응용개치，단기재일사량성종류화염증병변중적고표체야제시림상재CA19-9적응용중잉수주의대상관량성종류적감별분석。
Objective To evaluate the clinical application value of carbohydrate antigen 1 9-9 (CA1 9-9 )in different kinds of tumors.Methods Serum levels of CA19-9 were detected in 767 tumor or benign tumor patients (case group)and 288 health sub-jects (control group)by using chemoluminescence assay.Results Serum level of CA19-9 in control group was (14.2±8.9)IU/mL,which was significantly lower than case group.Serum levels of CA19-9 were with differences in patients with cancers of differ-ent systems,and those in patients with different types of cancers of the same system were also with differences,indicating that ser-um CA19-9 expression levels could be heterogeneous in cancer patients.Conclusion High serum expression levels of CA19-9 could be detected in patients with esophageal carcinoma,liver cancer,pancreatic cancer,or gallbladder carcinoma and so on,indicating that CA1 9-9 might be with important clinical value.But high expression levels of serum CA1 9-9 in some benign tumors might indicate that more attention should be paid for the differential diagnosis of benign tumors in clinical application.