国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
12期
1560-1561
,共2页
胃蛋白酶原%浅表性胃炎%时间分辨荧光法
胃蛋白酶原%淺錶性胃炎%時間分辨熒光法
위단백매원%천표성위염%시간분변형광법
pepsinogen%superficial gastritis%time-resolved fluoroimmunoassay
目的：探讨胃蛋白酶原Ⅰ（PGⅠ）和胃蛋白酶原Ⅱ（PGⅡ）与浅表性胃炎的关系。方法选择浅表性胃炎患者228例和健康体检人群2705例，分别检测PGⅠ和PGⅡ，比较2组之间的差异。对浅表性胃炎患者根据炎症强度或炎症活动性进行分组，分析PGⅠ和PGⅡ与炎症强度和炎症活动性的关系。结果浅表性胃炎患者血清 PGⅠ和 PGⅡ水平分别为（235．0±146．2）ng/mL和（22．3±14．8）ng/mL，均显著高于健康体检人群[PGⅠ为（154．3±62．1）ng/mL 和 PGⅡ为（15．9±11．0）ng/mL]，差异均有统计学意义（P＜0．05）。浅表性胃炎弱阳性组、阳性组、强阳性组血清PGⅠ水平分别为（175．5±90．9）、（230．1±148．2）、（270．4±146．6）ng/mL，表现出升高的趋势，阳性组PGⅠ水平显著高于弱阳性组，差异有统计学意义（P＜0．05）；PGⅡ水平分别为（16．3±6．8）、（19．9±13．9）、（25．1±9．2）ng/mL，阳性组血清PGⅡ水平显著高于弱阳性组，强阳性组显著高于阳性组，差异均有统计学意义（P＜0．05）。活动性胃炎患者血清PGⅠ、PGⅡ水平分别为（263．6±131．7）ng/mL和（24．7±9．8）ng/mL；非活动性胃炎患者血清PGⅠ、PGⅡ水平分别为（217．7±145．3）ng/mL和（18．6±13．3）ng/mL，2组患者PGⅠ和PGⅡ水平差异均有统计学意义（P＜0．05）。结论浅表性胃炎患者血清PGⅠ和PGⅡ均显著高于健康体检人群，并随着炎症强度和炎症活动性的增强而升高。
目的：探討胃蛋白酶原Ⅰ（PGⅠ）和胃蛋白酶原Ⅱ（PGⅡ）與淺錶性胃炎的關繫。方法選擇淺錶性胃炎患者228例和健康體檢人群2705例，分彆檢測PGⅠ和PGⅡ，比較2組之間的差異。對淺錶性胃炎患者根據炎癥彊度或炎癥活動性進行分組，分析PGⅠ和PGⅡ與炎癥彊度和炎癥活動性的關繫。結果淺錶性胃炎患者血清 PGⅠ和 PGⅡ水平分彆為（235．0±146．2）ng/mL和（22．3±14．8）ng/mL，均顯著高于健康體檢人群[PGⅠ為（154．3±62．1）ng/mL 和 PGⅡ為（15．9±11．0）ng/mL]，差異均有統計學意義（P＜0．05）。淺錶性胃炎弱暘性組、暘性組、彊暘性組血清PGⅠ水平分彆為（175．5±90．9）、（230．1±148．2）、（270．4±146．6）ng/mL，錶現齣升高的趨勢，暘性組PGⅠ水平顯著高于弱暘性組，差異有統計學意義（P＜0．05）；PGⅡ水平分彆為（16．3±6．8）、（19．9±13．9）、（25．1±9．2）ng/mL，暘性組血清PGⅡ水平顯著高于弱暘性組，彊暘性組顯著高于暘性組，差異均有統計學意義（P＜0．05）。活動性胃炎患者血清PGⅠ、PGⅡ水平分彆為（263．6±131．7）ng/mL和（24．7±9．8）ng/mL；非活動性胃炎患者血清PGⅠ、PGⅡ水平分彆為（217．7±145．3）ng/mL和（18．6±13．3）ng/mL，2組患者PGⅠ和PGⅡ水平差異均有統計學意義（P＜0．05）。結論淺錶性胃炎患者血清PGⅠ和PGⅡ均顯著高于健康體檢人群，併隨著炎癥彊度和炎癥活動性的增彊而升高。
목적：탐토위단백매원Ⅰ（PGⅠ）화위단백매원Ⅱ（PGⅡ）여천표성위염적관계。방법선택천표성위염환자228례화건강체검인군2705례，분별검측PGⅠ화PGⅡ，비교2조지간적차이。대천표성위염환자근거염증강도혹염증활동성진행분조，분석PGⅠ화PGⅡ여염증강도화염증활동성적관계。결과천표성위염환자혈청 PGⅠ화 PGⅡ수평분별위（235．0±146．2）ng/mL화（22．3±14．8）ng/mL，균현저고우건강체검인군[PGⅠ위（154．3±62．1）ng/mL 화 PGⅡ위（15．9±11．0）ng/mL]，차이균유통계학의의（P＜0．05）。천표성위염약양성조、양성조、강양성조혈청PGⅠ수평분별위（175．5±90．9）、（230．1±148．2）、（270．4±146．6）ng/mL，표현출승고적추세，양성조PGⅠ수평현저고우약양성조，차이유통계학의의（P＜0．05）；PGⅡ수평분별위（16．3±6．8）、（19．9±13．9）、（25．1±9．2）ng/mL，양성조혈청PGⅡ수평현저고우약양성조，강양성조현저고우양성조，차이균유통계학의의（P＜0．05）。활동성위염환자혈청PGⅠ、PGⅡ수평분별위（263．6±131．7）ng/mL화（24．7±9．8）ng/mL；비활동성위염환자혈청PGⅠ、PGⅡ수평분별위（217．7±145．3）ng/mL화（18．6±13．3）ng/mL，2조환자PGⅠ화PGⅡ수평차이균유통계학의의（P＜0．05）。결론천표성위염환자혈청PGⅠ화PGⅡ균현저고우건강체검인군，병수착염증강도화염증활동성적증강이승고。
Objective To evaluate the correlation of pepsinogen (PG)and superficial gastritis (SG).Methods Serum samples were collected from 228 SG patients and 2 705 healthy subjects and detected for PGⅠ and PGⅡ.Levels of PGⅠ and PGⅡ were compared between patients group and healthy subjects group.All of the 228 SG patients were divided into three groups according to the degree of inflammation,including weak positive group,positive group and strong positive group,and also divided into active group and non-active group according to inflammatory activity,to verify the relationship between PG and inflammation.Results Levels of PGⅠand PGⅡ in SG patients group were (235.0±146.2)and (22.3±14.8)ng/mL,respectively,both of which were higher than healthy subjects group (P<0.05).PGⅠ levels in weak positive group,positive group and strong positive group were (175.5±90.9),(230.1±148.2)and (270.4±146.6)ng/mL,respectively,which were with an increasing tendency.While PGⅡlevels in weak positive group,positive group and strong positive group were (16.3±6.8),(19.9±13.9)and (25.1±9.2)ng/mL, respectively,with statistically significant difference between each group (P<0.05).Levels of PGⅠ and PGⅡ of active inflamma-tion group were (263.6±131.7)and (24.7±9.8)ng/mL,respectively,both of which were higher than non-active inflammation group (P<0.05).Conclusion Levels of PGⅠ and PGⅡ in SG patients could be both higher than healthy subjects,and also might be with an increasing tendency with the intensity and activity of inflammation.
