CAJ | 학술논문

目的：探讨血清癌胚抗原（CEA）、糖类抗原（CA）724和CA199联合检测对胃癌的诊断价值。方法应用电化学发光法对胃癌患者95例、胃良性病变患者63例、健康对照者101例进行血清CEA、CA199及CA724三项肿瘤标志物的检测。结果胃癌组CEA、CA199、CA724单项检测水平及阳性率均显著高于健康对照组，差异有统计学意义（P＜0．05），CEA、CA724单项检测水平及阳性率也明显高于胃良性病变组，差异有统计学意义（P＜0．05），胃癌组CA199单项检测水平及阳性率与胃良性病变组比较差异无统计学意义（P＞0．05），3项肿瘤标志物联合检测的敏感度最高，高于2项联合检测及单项检测。结论联合检测3种肿瘤标志物有助于提高胃癌诊断的敏感性，对胃癌的辅助诊断具有临床价值。
목적：탐토혈청암배항원（CEA）、당류항원（CA）724화CA199연합검측대위암적진단개치。방법응용전화학발광법대위암환자95례、위량성병변환자63례、건강대조자101례진행혈청CEA、CA199급CA724삼항종류표지물적검측。결과위암조CEA、CA199、CA724단항검측수평급양성솔균현저고우건강대조조，차이유통계학의의（P＜0．05），CEA、CA724단항검측수평급양성솔야명현고우위량성병변조，차이유통계학의의（P＜0．05），위암조CA199단항검측수평급양성솔여위량성병변조비교차이무통계학의의（P＞0．05），3항종류표지물연합검측적민감도최고，고우2항연합검측급단항검측。결론연합검측3충종류표지물유조우제고위암진단적민감성，대위암적보조진단구유림상개치。
Objective To investigate the diagnostic value of combined detection of serum carcinoembryonic antigen (CEA),car-bohydrate antigen 199 (CA199)and carbohydrate antigen 724 (CA724)for the diagnosis of gastric cancer.Methods Plasma levels of CEA,CA199 and CA724 were detected by using electrochemiluminescence in 95 patients with gastric cancer,63 patients with be-nign gastric diseases and 101 healthy subjects.Results Levels and positive rates of CEA,CA199 and CA724 in gastric cancer group were significantly higher than healthy control group (P<0.05).Levels and positive rates of CEA and CA724 in gastric cancer group were significantly higher than benign gastric diseases group (P<0.05).There was no statistically significant difference of level and positive rate of CA199 between gastric cancer group and benign gastric diseases group(P>0.05).The sensitivity of com-bined detection was obviously higher than any single detection or combined detection of two indexesConclusion Combined detection of the three tumor markers could improve the diagnostic sensitivity and coincidence rate,which have practical diagnostic value for gastric cancer.