中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
18期
143-144,145
,共3页
原发性高血压%培哚普利%氨氯地平%左心室肥厚
原髮性高血壓%培哚普利%氨氯地平%左心室肥厚
원발성고혈압%배타보리%안록지평%좌심실비후
Essential hypertension%Perindopril%Amlodipine%Left ventricular hypertrophy
目的：观察培哚普利联合氨氯地平治疗原发性高血压合并左心室肥厚的临床疗效。方法：60例原发性高血压合并左心室肥厚患者，按照随机数字表法分为对照组和治疗组，每组30例。治疗组给予培哚普利4 mg/d，氨氯地平5 mg/d，对照组给予氨氯地平5 mg/d，两组疗程32周，观察治疗前后的血压、左室射血分数(LVEF)、左心室重量指数(LVMI)、左心室舒张末期内径(LVDd)、左室舒张末期室间隔厚度(IVS)、心室后壁厚度(PWT)变化。结果：治疗后，两组血压均明显降低，与本组治疗前比较差异均有统计学意义(P<0.05)。治疗后，治疗组收缩压、舒张压、心率均明显低于对照组，两组比较差异均有统计学意义(P<0.05)。治疗组IVS、PWT、LVDd、LVMI明显低于对照组，LVEF明显高于对照组，两组比较差异均有统计学意义(P<0.05)。结论：培哚普利联合氨氯地平治疗原发性高血压合并左心室肥厚患者降压效果显著，有协同降压作用，并能有效逆扭转左心室肥厚。
目的：觀察培哚普利聯閤氨氯地平治療原髮性高血壓閤併左心室肥厚的臨床療效。方法：60例原髮性高血壓閤併左心室肥厚患者，按照隨機數字錶法分為對照組和治療組，每組30例。治療組給予培哚普利4 mg/d，氨氯地平5 mg/d，對照組給予氨氯地平5 mg/d，兩組療程32週，觀察治療前後的血壓、左室射血分數(LVEF)、左心室重量指數(LVMI)、左心室舒張末期內徑(LVDd)、左室舒張末期室間隔厚度(IVS)、心室後壁厚度(PWT)變化。結果：治療後，兩組血壓均明顯降低，與本組治療前比較差異均有統計學意義(P<0.05)。治療後，治療組收縮壓、舒張壓、心率均明顯低于對照組，兩組比較差異均有統計學意義(P<0.05)。治療組IVS、PWT、LVDd、LVMI明顯低于對照組，LVEF明顯高于對照組，兩組比較差異均有統計學意義(P<0.05)。結論：培哚普利聯閤氨氯地平治療原髮性高血壓閤併左心室肥厚患者降壓效果顯著，有協同降壓作用，併能有效逆扭轉左心室肥厚。
목적：관찰배타보리연합안록지평치료원발성고혈압합병좌심실비후적림상료효。방법：60례원발성고혈압합병좌심실비후환자，안조수궤수자표법분위대조조화치료조，매조30례。치료조급여배타보리4 mg/d，안록지평5 mg/d，대조조급여안록지평5 mg/d，량조료정32주，관찰치료전후적혈압、좌실사혈분수(LVEF)、좌심실중량지수(LVMI)、좌심실서장말기내경(LVDd)、좌실서장말기실간격후도(IVS)、심실후벽후도(PWT)변화。결과：치료후，량조혈압균명현강저，여본조치료전비교차이균유통계학의의(P<0.05)。치료후，치료조수축압、서장압、심솔균명현저우대조조，량조비교차이균유통계학의의(P<0.05)。치료조IVS、PWT、LVDd、LVMI명현저우대조조，LVEF명현고우대조조，량조비교차이균유통계학의의(P<0.05)。결론：배타보리연합안록지평치료원발성고혈압합병좌심실비후환자강압효과현저，유협동강압작용，병능유효역뉴전좌심실비후。
Objective:To observe the clinical efficacy of perindopril and amlodipine in the treatment of essential hypertension and left ventricular hypertrophy. Method:60 patients with essential hypertension and left ventricular hypertrophy were randomly divided into control group of 30 patients and treatment group of 30 patients. Treatment group was treated with perindopril tablets(4 mg,one time per day),amlodipine tablets(5 mg,one time per day),whil control group was treated with amlodipine tablets(5 mg,one time per day),both groups were treated for 32 weeks. Observed the changes of blood pressure,LVEF, LVMI,LVDd,IVS,PWT in the two groups before and after treatment. Result:The blood pressure of the two groups after treatment were significantly lower than those before treatment(P<0.05). The systolic blood pressure,diastolic blood pressure,heart rate of the treatment group was significantly lower than that in control group (P<0.05). IVS,PWT,LVDd,LVMI after treatment were significantly lower than those in control group,LVEF was significantly higher than that in control group(P<0.05). Conclusion:Perindopril and amlodipine in treatment of essential hypertension and left ventricular hypertrophy can significantly reduce the blood pressure and effectively reverse left ventricular hypertrophy.
