中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
18期
119-120
,共2页
CO2激光%膦甲酸钠%复发性尖锐湿疣%血清细胞因子
CO2激光%膦甲痠鈉%複髮性尖銳濕疣%血清細胞因子
CO2격광%련갑산납%복발성첨예습우%혈청세포인자
CO2 laser%Foscarnet Sodium%Recurrent condyloma acuminatum%Serum levels of cytokines
目的：观察CO2激光联合膦甲酸钠对复发性尖锐湿疣患者血清Th1/Th2细胞因子的影响。方法：选取笔者所在医院收治的30例复发性尖锐湿疣的患者设为观察组，选取同期健康体检者30例设为对照组。观察组给予CO2激光联合膦甲酸钠治疗，对照组体检者不做任何特殊处理。使用ELISA方法对两组患者血清水平进行检查，对比观察组患者接受治疗前、接受治疗后的血清IL-4以及IFN-γ水平。结果：观察组患者接受治疗前血清IL-4水平明显高于对照组，IFN-γ水平明显低于对照组；观察组患者接受治疗后血清IL-4水平明显低于接受治疗前，IFN-γ水平明显高于接受治疗前，差异均有统计学意义(P<0.05)。结论：CO2激光联合膦甲酸钠方案可增强Th1介导细胞免疫，抑制Th2介导体液免疫，平衡血清Th1/Th2细胞因子促进人乳头瘤病毒的清除，对于防止复发性尖锐湿疣复发有重要价值，值得临床关注与重视。
目的：觀察CO2激光聯閤膦甲痠鈉對複髮性尖銳濕疣患者血清Th1/Th2細胞因子的影響。方法：選取筆者所在醫院收治的30例複髮性尖銳濕疣的患者設為觀察組，選取同期健康體檢者30例設為對照組。觀察組給予CO2激光聯閤膦甲痠鈉治療，對照組體檢者不做任何特殊處理。使用ELISA方法對兩組患者血清水平進行檢查，對比觀察組患者接受治療前、接受治療後的血清IL-4以及IFN-γ水平。結果：觀察組患者接受治療前血清IL-4水平明顯高于對照組，IFN-γ水平明顯低于對照組；觀察組患者接受治療後血清IL-4水平明顯低于接受治療前，IFN-γ水平明顯高于接受治療前，差異均有統計學意義(P<0.05)。結論：CO2激光聯閤膦甲痠鈉方案可增彊Th1介導細胞免疫，抑製Th2介導體液免疫，平衡血清Th1/Th2細胞因子促進人乳頭瘤病毒的清除，對于防止複髮性尖銳濕疣複髮有重要價值，值得臨床關註與重視。
목적：관찰CO2격광연합련갑산납대복발성첨예습우환자혈청Th1/Th2세포인자적영향。방법：선취필자소재의원수치적30례복발성첨예습우적환자설위관찰조，선취동기건강체검자30례설위대조조。관찰조급여CO2격광연합련갑산납치료，대조조체검자불주임하특수처리。사용ELISA방법대량조환자혈청수평진행검사，대비관찰조환자접수치료전、접수치료후적혈청IL-4이급IFN-γ수평。결과：관찰조환자접수치료전혈청IL-4수평명현고우대조조，IFN-γ수평명현저우대조조；관찰조환자접수치료후혈청IL-4수평명현저우접수치료전，IFN-γ수평명현고우접수치료전，차이균유통계학의의(P<0.05)。결론：CO2격광연합련갑산납방안가증강Th1개도세포면역，억제Th2개도체액면역，평형혈청Th1/Th2세포인자촉진인유두류병독적청제，대우방지복발성첨예습우복발유중요개치，치득림상관주여중시。
Objective:To observe the effect of CO2 laser combined with Foscarnet Sodium on serum levels of Th1/Th2 cytokines in patients with recurrent condyloma acuminatum.Method:30 cases of condyloma acuminatum recurrent were selected in author’s hospital as the observation group,30 cases of healthy people were selected as control group.The observation group was given the CO2 laser with Foscarnet Sodium therapy and the control group medical don’t any special treatment. Using ELISA method inspection on serum levels of two groups of patients,the contrast observation group of patients before treatment and after treatment serum IL-4 and IFN-γlevels.Result:The observation group of patients before treatment was significantly higher than the control group, serum levels of IL-4,IFN-γlevels significantly lower than the control group. Observation group of patients after treatment was significantly lower than the level of serum IL-4 before treatment,IFN-γlevel was significantly higher than those before treatment,the differences were statistically significant(P<0.05). Conclusion:CO2 laser combined with Foscarnet Sodium can enhance Th1 mediated and inhibition of Th2 mediated cellular immune,humoral immune,serum Th1/Th2 cytokines balance accelerate the clearance of HPV,to prevent the recurrence of condyloma acuminatum recurrence has important value,is worthy of attention and attention.
