CAJ | 학술논문

背景：炎症牙髓干细胞是近年来新发现的一类牙髓干细胞，目前尚无对其研究进展的系统评价。目的：系统评价炎症牙髓干细胞的研究进展。方法：以“(Pulptis OR Inflam* Dental Pulp* OR Human Dental Pulp with Irreversible Pulpitis)AND Stem Cel*/(牙髓炎OR炎症牙髓OR不可逆性牙髓炎)AND干细胞”为检索词检索PubMed、Web of Science、CNKI、WanFang及VIP数据库(时间：建库至2014年2月)，同时手检纳入研究的参考文献。对研究结果进行定性分析，进行炎症牙髓干细胞研究进展的全面总结。结果与结论：共纳入11篇文献进行研究，全面阐述炎症牙髓干细胞的研究历史、材料来源、细胞培养、表面标志、扩增能力、多向分化能力、动物模型及临床应用前景的研究进展。炎症牙髓干细胞研究尚处于起步，培养条件和动物模型的建立正处于探究阶段，扩增能力和多向分化能力研究结果尚有争议，而在免疫特性、亚群研究和临床应用方面研究较少。
배경：염증아수간세포시근년래신발현적일류아수간세포，목전상무대기연구진전적계통평개。목적：계통평개염증아수간세포적연구진전。방법：이“(Pulptis OR Inflam* Dental Pulp* OR Human Dental Pulp with Irreversible Pulpitis)AND Stem Cel*/(아수염OR염증아수OR불가역성아수염)AND간세포”위검색사검색PubMed、Web of Science、CNKI、WanFang급VIP수거고(시간：건고지2014년2월)，동시수검납입연구적삼고문헌。대연구결과진행정성분석，진행염증아수간세포연구진전적전면총결。결과여결론：공납입11편문헌진행연구，전면천술염증아수간세포적연구역사、재료래원、세포배양、표면표지、확증능력、다향분화능력、동물모형급림상응용전경적연구진전。염증아수간세포연구상처우기보，배양조건화동물모형적건립정처우탐구계단，확증능력화다향분화능력연구결과상유쟁의，이재면역특성、아군연구화림상응용방면연구교소。
BACKGROUND:Inflamed dental pulp stem cells are a new kind of dental pulp stem cells, and there is no systematic review on the cells by now. OBJECTIVE:To systematical y review the research progress in inflamed dental pulp stem cells. METHODS:A computer-based online search in PubMed, Web of Science, CNKI, WanFang and VIP databases was performed for related articles published from the establishment of the databases to February 2014. The keywords were“(pulptis or inflam*dental pulp*or human dental pulp with irreversible pulpitis) and stem cel*”in English and Chinese, respectively. Hand searching was also done to obtain further information or papers about the studies. The results were qualitatively analyzed to comprehensively summarize the progress in the research of inflamed dental pulp stem cells. RESULTS AND CONCLUSION:Total y 11 papers were involved in result analysis that comprehensively review the research progress in inflamed dental pulp stem cells at the fol owing aspects:the research of history, material origin, cellculture, cel-surface markers, proliferation ability, multi-directional differentiation potential, animal models and clinical use. Researches of inflamed dental pulp stem cells are stil in the initial stage, and cultivating conditions and the establishment of animal models are stil in the exploratory phase. Controversies stil exist in the capacity of proliferation and multi-directional differentiation of the inflamed dental pulp stem cells. And fewer studies have been done in the characteristics of immunity, subpopulation and clinical use of the inflamed dental pulp stem cells.