CAJ | 학술논문

目的：探讨心得安于婴幼儿血管瘤治疗中的应用价值与安全性。方法：选取血管瘤患儿83例，第1天每次0.5mg/kg（体重），第2天，每次0.75mg/kg（体重），第2天及以后，每次1.0mg/kg（体重），每日早晚8点各1次。观察和比较治疗前后血管瘤的颜色、大小、相关指标、PSV、RI。结果：不同性别、不同发生部位间疗效分布差异无统计学意义（P＞0.05）；浅表型优良率69.77%优于深部型15.79%、混合型52.38%，治疗持续8个月患者PSV、RI分别为（23.0±5.2）cm/s、（0.85±0.11）优于治疗前（68.3±12.3）cm/s、（0.53±0.14），差异具有统计学意义（P＜0.05）；未见严重不良反应。结论：心得安治疗婴幼儿血管瘤疗效显著，安全可靠，但疗效受血管瘤类型影响。
목적：탐토심득안우영유인혈관류치료중적응용개치여안전성。방법：선취혈관류환인83례，제1천매차0.5mg/kg（체중），제2천，매차0.75mg/kg（체중），제2천급이후，매차1.0mg/kg（체중），매일조만8점각1차。관찰화비교치료전후혈관류적안색、대소、상관지표、PSV、RI。결과：불동성별、불동발생부위간료효분포차이무통계학의의（P＞0.05）；천표형우량솔69.77%우우심부형15.79%、혼합형52.38%，치료지속8개월환자PSV、RI분별위（23.0±5.2）cm/s、（0.85±0.11）우우치료전（68.3±12.3）cm/s、（0.53±0.14），차이구유통계학의의（P＜0.05）；미견엄중불량반응。결론：심득안치료영유인혈관류료효현저，안전가고，단료효수혈관류류형영향。
Objective:To investigate the application value and safety experience of infantile hemangioma treatment with propranolol. Methods:Selecting 83 children with hemangiomas, 0.5mg/kg(weight) the first day, 0.75mg/kg(weight) the second day, and 1.0mg/kg(weight) every time after the second day with 1 time 8:00 in the morning and afternoon. The color, size, related indicators, PSV and RI of hemangioma were observed and compared. Results:There no statistically significant effect of sex distribution differences among different parts (P>0.05); superficial good rate is 69.77%, which is better than 15.79% of deep type, 52.38% of mixed type. PSV and RI of patients treated for 8 months are(23.0 ± 5.2) cm / s and (0.85 ± 0.11), which are better than (68.3±12.3)cm/s,(0.53±0.14)cm/s before treatment. The difference was statistically significant (P<0.05), with no severe adverse reactions. Conclusion:Propranolol treatment of infantile hemangioma has significant effect, with safe and reliable, but the effects are influenced by the type of hemangioma.