CAJ | 학술논문

目的：探讨患者体内纤维蛋白原（ FIB）、超敏C－反应蛋白（ CRP）及血气分析在慢性阻塞性肺疾病（ COPD）中的变化及临床意义。方法：采集72例慢性阻塞性肺疾病患者入院时、治疗10天后病情平稳血标本，测定纤维蛋白原、超敏CRP及动脉血气分析，用52例正常体检者作为对照。结果：患者组治疗前纤维蛋白原、超敏CRP与治疗后及对照组间比较，差异均有统计学意义（P＜0．05）。且患者组治疗前FIB与CRP成正相关，与PaO2和SaO2均呈负相关。结论：凝血纤溶功能异常在COPD的发生及发展中起重要作用，且与CRP和缺氧有密切联系。
목적：탐토환자체내섬유단백원（ FIB）、초민C－반응단백（ CRP）급혈기분석재만성조새성폐질병（ COPD）중적변화급림상의의。방법：채집72례만성조새성폐질병환자입원시、치료10천후병정평은혈표본，측정섬유단백원、초민CRP급동맥혈기분석，용52례정상체검자작위대조。결과：환자조치료전섬유단백원、초민CRP여치료후급대조조간비교，차이균유통계학의의（P＜0．05）。차환자조치료전FIB여CRP성정상관，여PaO2화SaO2균정부상관。결론：응혈섬용공능이상재COPD적발생급발전중기중요작용，차여CRP화결양유밀절련계。
Objective:To investigate the changes and clinical significances of the fibrinogen (FIB),high sensitivity C-reactive protein ( CRP) and blood gas analysis in the patients with chronic obstructive pulmonary disease ( COPD) .Meth-ods:Fibrinogen,levels of serum CRP and arteria blood gas analysis were detected in 72 COPD patients before and after treatment as well as in 52 healthy controls .Results:Fibrinogen and levels of serum CRP were significantly higher in COPD patients before treatment than those after treatmen and healthy controls (P<0.05).Fibrinogen in COPD patients was posi-tively correlations with serum CRP ,and that was negative correlations with PaO 2 and SaO2 .Conclusion:Coagulation and fi-brinolysis dys-function plays an important role in the occurrence and development of COPD ,and is closely linked with the CRP and hypoxia .