CAJ | 학술논문

目的：系统评价艾迪注射液联合局部放疗与单纯放疗比较治疗食管癌的临床疗效。方法：采用Co-chrane 系统评价的方法，检索PubMed、中文科技期刊全文数据库、中国期刊全文数据库、万方数据库、Cochrane 图书馆临床对照试验库等，检索时间均为各数据库建库至2013年10月，纳入艾迪注射液联合放疗治疗食管癌的随机对照研究，由2名评价者独立评价并交叉核对纳入研究质量，对纳入的研究采用Rev Man 5．0软件进行Meta分析。结果：共纳入8项研究，均为低质量研究。系统评价分析结果显示，与单纯放疗方案比较，艾迪注射液与放疗联合可有效改善患者近期疗效[OR＝1．88，95％CI（1．23，2．85），P＝0．003，提高患者生存质量[OR＝1．98，95％CI（1．67，2．34），P＝0．002]，缓解放疗后放射性食管炎的发生[OR＝0．41，95％CI（0．26，0．67）P＝0．0003]，减少血液学毒性[OR＝0．25，95％CI（0．16，0．40），P＜0．00001]。结论：艾迪注射液联合放疗对晚期食管癌有很好的辅助治疗作用，能够改善近期疗效，提高生存质量。
목적：계통평개애적주사액연합국부방료여단순방료비교치료식관암적림상료효。방법：채용Co-chrane 계통평개적방법，검색PubMed、중문과기기간전문수거고、중국기간전문수거고、만방수거고、Cochrane 도서관림상대조시험고등，검색시간균위각수거고건고지2013년10월，납입애적주사액연합방료치료식관암적수궤대조연구，유2명평개자독립평개병교차핵대납입연구질량，대납입적연구채용Rev Man 5．0연건진행Meta분석。결과：공납입8항연구，균위저질량연구。계통평개분석결과현시，여단순방료방안비교，애적주사액여방료연합가유효개선환자근기료효[OR＝1．88，95％CI（1．23，2．85），P＝0．003，제고환자생존질량[OR＝1．98，95％CI（1．67，2．34），P＝0．002]，완해방료후방사성식관염적발생[OR＝0．41，95％CI（0．26，0．67）P＝0．0003]，감소혈액학독성[OR＝0．25，95％CI（0．16，0．40），P＜0．00001]。결론：애적주사액연합방료대만기식관암유흔호적보조치료작용，능구개선근기료효，제고생존질량。
Objective:To evaluate the Clinical efficacy of Aidi injection combined with radiotherapy vs .radiotherapy monotherapy alone for esophageal carcinoma .Methods:We searched the Cochrane Library ,PubMed,VIP,Wanfang Data-base and CNKI by computer .The retrieval time was from the building of the datebase to October 2013 .Randomized con-trolled trials ( RCTs) about Aidi injection combined with radiotherapy for esophageal carcinoma were included .The quality of included trials were evaluated by two reviewers independently .Meta-analysis was carried out with RevMan 5.2 software. Results:8 RCTs were included in the meta-analysis,but the quality of reports was poor .Results of meta-analysis showed that Aidi injection combined with radiotherapy could effectively improve short -term efficacy[OR=1.88,95%CI(1.23,2.85),P<0.01],improve patients'quality of life [OR=1.98,95%CI (1.67,2.34),P<0.01],reduce the incidence of ra-diation esophagit [OR=0.41,95%CI (0.26,0.67),P<0.01]and bone marrow suppression[OR=0.25,95%CI(0.16, 0.40),P<0.01].Conclusion:Aidi injection combined with radiotherapy may be an effective regimen in the treatment of esophageal Carcinoma by improving patients short-term efficacy and life quality;reducing the the incidence of radiation esophagit and bone marrow suppression .