交通医学
交通醫學
교통의학
MEDICAL JOURNAL OF COMMUNICATIONS
2014年
3期
214-217
,共4页
2型糖尿病%血浆生长抑素%糖化血红蛋白%高胰岛素血症%轻度认知功能障碍
2型糖尿病%血漿生長抑素%糖化血紅蛋白%高胰島素血癥%輕度認知功能障礙
2형당뇨병%혈장생장억소%당화혈홍단백%고이도소혈증%경도인지공능장애
Type 2 diabetes mellitus%somatostatin%HbA1c%hyperinsulinemia%mild cognitive impairment
目的：探讨2型糖尿病患者空腹血清生长抑素（FSS）与轻度认知功能障碍（MCI）得关系。方法：2型糖尿病患者110例作为观察组，根据是否有认知功能障碍分为MCI组（A组）和认知功能正常组（B组）。正常对照组40例为正常体检者。对A组进行MoCA评测。测定3组空腹血浆生长抑素（FSS）、空腹胰岛素（FINS）、空腹C肽（FC-P）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）；体重指数（BMI）。结果：⑴FSS：A组33.35±9.62 pg/mL，B组38.86±10.69 pg/mL，对照组32.44±8.08 pg/mL，3组FSS比较，B组较A组、对照组明显升高，差异有统计学意义（P<0.05），A组与对照组差异无统计学意义（P>0.05）。⑵糖尿病患者MCI组MoCA评分与FSS呈正相关（P＜0.01），与FINS（P＜0.01）、HbA1c（P＜0.05）呈负相关。⑶Logistic回归分析显示，FSS、学历、HbA1c、TG、年龄是与2型糖尿病轻度认知功能障碍密切相关的独立影响因素（P＜0.05）。结论：FSS是MCI的保护因素，可能参与2型糖尿病轻度认知功能障碍的发生发展，对T2DM患者FSS进行早期监测和积极干预，有利于改善T2DM患者的认知功能。
目的：探討2型糖尿病患者空腹血清生長抑素（FSS）與輕度認知功能障礙（MCI）得關繫。方法：2型糖尿病患者110例作為觀察組，根據是否有認知功能障礙分為MCI組（A組）和認知功能正常組（B組）。正常對照組40例為正常體檢者。對A組進行MoCA評測。測定3組空腹血漿生長抑素（FSS）、空腹胰島素（FINS）、空腹C肽（FC-P）、空腹血糖（FPG）、糖化血紅蛋白（HbA1c）、總膽固醇（TC）、甘油三酯（TG）；體重指數（BMI）。結果：⑴FSS：A組33.35±9.62 pg/mL，B組38.86±10.69 pg/mL，對照組32.44±8.08 pg/mL，3組FSS比較，B組較A組、對照組明顯升高，差異有統計學意義（P<0.05），A組與對照組差異無統計學意義（P>0.05）。⑵糖尿病患者MCI組MoCA評分與FSS呈正相關（P＜0.01），與FINS（P＜0.01）、HbA1c（P＜0.05）呈負相關。⑶Logistic迴歸分析顯示，FSS、學歷、HbA1c、TG、年齡是與2型糖尿病輕度認知功能障礙密切相關的獨立影響因素（P＜0.05）。結論：FSS是MCI的保護因素，可能參與2型糖尿病輕度認知功能障礙的髮生髮展，對T2DM患者FSS進行早期鑑測和積極榦預，有利于改善T2DM患者的認知功能。
목적：탐토2형당뇨병환자공복혈청생장억소（FSS）여경도인지공능장애（MCI）득관계。방법：2형당뇨병환자110례작위관찰조，근거시부유인지공능장애분위MCI조（A조）화인지공능정상조（B조）。정상대조조40례위정상체검자。대A조진행MoCA평측。측정3조공복혈장생장억소（FSS）、공복이도소（FINS）、공복C태（FC-P）、공복혈당（FPG）、당화혈홍단백（HbA1c）、총담고순（TC）、감유삼지（TG）；체중지수（BMI）。결과：⑴FSS：A조33.35±9.62 pg/mL，B조38.86±10.69 pg/mL，대조조32.44±8.08 pg/mL，3조FSS비교，B조교A조、대조조명현승고，차이유통계학의의（P<0.05），A조여대조조차이무통계학의의（P>0.05）。⑵당뇨병환자MCI조MoCA평분여FSS정정상관（P＜0.01），여FINS（P＜0.01）、HbA1c（P＜0.05）정부상관。⑶Logistic회귀분석현시，FSS、학력、HbA1c、TG、년령시여2형당뇨병경도인지공능장애밀절상관적독립영향인소（P＜0.05）。결론：FSS시MCI적보호인소，가능삼여2형당뇨병경도인지공능장애적발생발전，대T2DM환자FSS진행조기감측화적겁간예，유리우개선T2DM환자적인지공능。
Objective: To investigate the possibility of somatostatin (SS) as a potential early marker in patients with Type 2 diabetes and mild cognitive impairment (MCI). Methods: According to Petersen MCI diagnosis standard recom-mended by the Mayo research center of neurology, and MCI diagnosis standard by Shanghai Mental Health Center, a total of 110 patients with Type 2 diabetes were divided into two groups:T2DM with MCI (Group A) and T2DM without MCI (Group B). At the same time 40 physical examinees with ages and sexes corresponding to those of the research groups con-stituted a healthy control group(Group C). All Type 2 diabetic patients were also assessed by MoCA. Serum levels of SS were measured, other clinical parameters were also measured., such as FINS, FC-P, FPG, HbA1c, TC, TG and BMI. Result:s⑴FSS: Group A showed 33.35±9.62 pg/mL; Group B, 38.86±10.69 pg/mL; Group C, 32.44±8.08 pg/mL. there was significant difference in Group B compared with Groups A and C (P<0.01);there was no significant difference in Group A and Group C (P>0.05).⑵Compared with the T2DM patients of the normal cognitive function, MCI patients had a lower level of SS and e-ducation background, a higher age, elevated HbA1c, HCY, FINS and F-CP.3. FSS and MoCA scores in T2DM with MCI pa-tients presented significantly positive correlation (P<0.01), and FINS and HbA1c presented significantly negative correlation (P<0.05). ⑶ In Logistic regressive analysis, FSS, education background, HbA1c, Tg and ages were independent influential factors that were closely related with MCI inType 2 diabetes (P>0.05). Conclusion:FSS was a protective factor of MCI, and SS played an important role in the occurrence and development of MCI, providing a novel thought about interference of MCI.
