CAJ | 학술논문

表观遗传学是研究基因的核苷酸序列不发生改变的情况下，基因表达或蛋白表达发生可遗传的变化，但又可以通过细胞发育和增殖而稳定遗传现象的一门遗传学分支学科。表观遗传学的研究内容包括 DNA 甲基化、组蛋白共价修饰、mRNA 编辑、染色体重塑、基因沉默等。其调控机制是：细胞内功能基因的选择性激活或灭活。表观基因相对于整个基因组本身，提供了更有序、更特定的基因信息。表观遗传的异常会导致表型的改变，表现为人类疾病，如肿瘤。因此，随着人们对表观遗传学认识的深入，表观遗传学将成为生物医学研究领域的重点。
표관유전학시연구기인적핵감산서렬불발생개변적정황하，기인표체혹단백표체발생가유전적변화，단우가이통과세포발육화증식이은정유전현상적일문유전학분지학과。표관유전학적연구내용포괄 DNA 갑기화、조단백공개수식、mRNA 편집、염색체중소、기인침묵등。기조공궤제시：세포내공능기인적선택성격활혹멸활。표관기인상대우정개기인조본신，제공료경유서、경특정적기인신식。표관유전적이상회도치표형적개변，표현위인류질병，여종류。인차，수착인문대표관유전학인식적심입，표관유전학장성위생물의학연구영역적중점。
Epigenetics is the branch subject which studies the heritable changes of gene expression or protein expression without changing nucleotide sequence, and can make the phenomenon of heredity stable by cell development and proliferation. Epigenetics includes DNA methylation, histone covalent modification, mRNA editing, chromatin remodeling, gene silencing, etc. Its regulation mechanism is to activate or inactivate the function gene in the cells. It provides higher-ordered and more specified genetic information, compared with whole genome itself. Genetic anomaly may lead to alterations of phenotypes, such as human tumors. Therefore, with people’s in-depth understanding of epigenetics, epigenetics will become the focus of biomedical research.