CAJ | 학술논문

目的：研究CD200蛋白在皮肤鳞癌不同进展阶段中的变化趋势。方法收集正常皮肤、日光性角化病、鲍温病、鳞癌、浸润鳞癌的皮肤组织标本各20例，免疫组织化学法检测CD200蛋白在组织中的表达。结果日光性角化、鲍温病、鳞癌和浸润鳞癌组织CD200的表达比例均较正常组织显著增高（ P＜0．01）；鳞癌和浸润鳞癌组织CD200的表达比例较日光性角化及鲍温病均显著增高（P＜0．01）。结论 CD200的高表达可能促进了皮肤鳞癌的进展。
목적：연구CD200단백재피부린암불동진전계단중적변화추세。방법수집정상피부、일광성각화병、포온병、린암、침윤린암적피부조직표본각20례，면역조직화학법검측CD200단백재조직중적표체。결과일광성각화、포온병、린암화침윤린암조직CD200적표체비례균교정상조직현저증고（ P＜0．01）；린암화침윤린암조직CD200적표체비례교일광성각화급포온병균현저증고（P＜0．01）。결론 CD200적고표체가능촉진료피부린암적진전。
Objective To study the trend of CD200 expression in different stages of squamous cell carcinoma .Methods To collect specimens of normal skin, actinic keratosis, Bowen's disease, squamous cell carcinoma and invasion squamous cell carcinoma and to detect the expression of CD 200 by immunohistochemical method .Results Compared with normal skin , a significant increase is found in CD200 expression in actinic keratosis, Bowen’s disease, squamous cell carcinoma and invasion squamous cell carcinoma (P<0.01). Compared with actinic keratosis and Bowen's disease, a significant increase is found in CD200 expression in squamous cell carcinoma and invasion squamous cell carcinoma (P<0.01).Conclusion High expression of CD200 may promote progression of squamous cell carcinoma.