CAJ | 학술논문

代谢综合征（包括腹型肥胖、糖代谢异常、脂代谢紊乱、高血压等）因与心血管病风险因素密切相关，已成为全球公共健康的一个主要挑战。绝经后激素治疗的应用已有半个多世纪，但绝经后激素治疗（ menopause hormone therapy ，MHT）的适应证及理想候选适应证仍然不清楚。绝经妇女心血管病风险的增高是这组人群死亡的主要原因。雌激素的降低与许多围绝经与绝经后妇女总胆固醇、三酰甘油、低密度脂蛋白胆固醇的增加，胰岛素抵抗的增加及血压的升高相关。这些变化的参数是代谢综合征的主要组分。目前推荐MHT作为血管舒缩症状的金标准治疗，其对代谢综合征组分及心血管病风险的益处仍不清楚，本文将对MHT与代谢综合征组分的风险及益处进行综述。
대사종합정（포괄복형비반、당대사이상、지대사문란、고혈압등）인여심혈관병풍험인소밀절상관，이성위전구공공건강적일개주요도전。절경후격소치료적응용이유반개다세기，단절경후격소치료（ menopause hormone therapy ，MHT）적괄응증급이상후선괄응증잉연불청초。절경부녀심혈관병풍험적증고시저조인군사망적주요원인。자격소적강저여허다위절경여절경후부녀총담고순、삼선감유、저밀도지단백담고순적증가，이도소저항적증가급혈압적승고상관。저사변화적삼수시대사종합정적주요조분。목전추천MHT작위혈관서축증상적금표준치료，기대대사종합정조분급심혈관병풍험적익처잉불청초，본문장대MHT여대사종합정조분적풍험급익처진행종술。
The metabolic syndrome ( including visceral obesity , dyslipidemia , hyperglycemia , and hypertension ) has become one of the major public-health challenges worldwide .The menopause hormone therapy ( MHT) is in use for more than a half of century , but the question of indications and ideal candidates for hormone replacement therapy ( HRT ) remains unclear .Postmenopausal women are a population with the increasing risks for cardiovascular diseases which are the main cause of death in this group .Decline in estrogen concentrations is linked to a number of changes in peri and postmenopause: increased total cholesterol , triglycerides , and low density lipoprotein, increased insulin resistance and increased blood pressure etc .These changes are the main components of metabolic syndrome . HRT is currently recommended as the gold standard for the management of vasomotor symptoms , but the benefit of MHT on components of metabolic syndrome and risk for cardiovascular events risk is still uncertain .This review will focus on MHT risk and benefit issues .