CAJ | 학술논문

上皮细胞-间叶细胞转化（epithelial to mesenchymal transition, EMT）不仅在胚胎的发育过程中起着十分重要的作用，还参与非小细胞肺癌（non-small cell lung cancer, NSCLC）的转移过程。近期的研究发现，发生EMT的细胞不仅出现了形态的改变，还出现了相关表型的改变。既往有关EMT发生机制的研究多数是针对其他肿瘤的，因此很有必要研究NSCLC中是否有类似发生机制。随着研究的进展，EMT相关的基础研究逐渐被用于预测NSCLC的预后。本文将对NSCLC中EMT的发生机制及其临床应用的研究进展进行探讨。
상피세포-간협세포전화（epithelial to mesenchymal transition, EMT）불부재배태적발육과정중기착십분중요적작용，환삼여비소세포폐암（non-small cell lung cancer, NSCLC）적전이과정。근기적연구발현，발생EMT적세포불부출현료형태적개변，환출현료상관표형적개변。기왕유관EMT발생궤제적연구다수시침대기타종류적，인차흔유필요연구NSCLC중시부유유사발생궤제。수착연구적진전，EMT상관적기출연구축점피용우예측NSCLC적예후。본문장대NSCLC중EMT적발생궤제급기림상응용적연구진전진행탐토。
Epithelial to mesenchymal transition (EMT) has an important role in the development of embryo, as well as that in the metastasis of non-small cell lung cancer (NSCLC). Recent researches have demonstrated that both morpho-logical and phenotypic conversions emerge in cells undergoing EMT. As most of relevant studies were on other cancers, it is es-sential to uncover whether it is the similar mechanisms accounting for EMT in NSCLC. With the progress of the studies, EMT-related basic researches are gradually applied to predicting the prognosis of NSCLC. hTe aim of this article was to discuss the mechanisms related to EMT emerging in NSCLC.