CAJ | 학술논문

目的：分析 H 型高血压与颈动脉斑块发生及性质的相关性。方法运用256层螺旋 CT 对198例原发性高血压患者行颈动脉血管造影检查。依据血浆同型半胱氨酸(homocysteine,Hcy)水平将其分为 H 型及非 H 型高血压2组,比较2组患者颈动脉斑块发生及性质的差异。再按照血压水平分层,分别比较2组上述的差异。结果颈动脉总斑块在2组间的构成(OR =1.931,95% CI 1.035~3.601,χ2=4.281,P=0.039)及颈动脉不稳定斑块在2组间的构成(OR=2.780,95% CI 1.631~4.738,χ2=14.123,P=0.000)差异有统计学意义,而颈动脉稳定斑块在2组间的构成(OR=1.622,χ2=2.731,P =0.098)差异无统计学意义；按血压水平分层,颈动脉总斑块在2组间的构成(ORMH =2.137,95% CI 1.723~2.651,χ2=47.767,P =0.000)及颈动脉不稳定斑块在2组间的构成(ORMH =2.971,95% CI 1.649~5.354,χ2=13.135,P =0.000)差异仍有统计学意义。结论颈动脉斑块的发生及斑块的不稳定性均与 H 型高血压有关,且不受血压水平的影响。
목적：분석 H 형고혈압여경동맥반괴발생급성질적상관성。방법운용256층라선 CT 대198례원발성고혈압환자행경동맥혈관조영검사。의거혈장동형반광안산(homocysteine,Hcy)수평장기분위 H 형급비 H 형고혈압2조,비교2조환자경동맥반괴발생급성질적차이。재안조혈압수평분층,분별비교2조상술적차이。결과경동맥총반괴재2조간적구성(OR =1.931,95% CI 1.035~3.601,χ2=4.281,P=0.039)급경동맥불은정반괴재2조간적구성(OR=2.780,95% CI 1.631~4.738,χ2=14.123,P=0.000)차이유통계학의의,이경동맥은정반괴재2조간적구성(OR=1.622,χ2=2.731,P =0.098)차이무통계학의의；안혈압수평분층,경동맥총반괴재2조간적구성(ORMH =2.137,95% CI 1.723~2.651,χ2=47.767,P =0.000)급경동맥불은정반괴재2조간적구성(ORMH =2.971,95% CI 1.649~5.354,χ2=13.135,P =0.000)차이잉유통계학의의。결론경동맥반괴적발생급반괴적불은정성균여 H 형고혈압유관,차불수혈압수평적영향。
Objective To study the correlation between type H hypertension and incidence and characteristics of carotid arterio-sclerosis plaques.Methods 1 98 patients with primary hypertension underwent 256-slice spiral CT carotid angiography.According to the level of homocysteine,the subjects were divided into two groups with type H and non-type H hypertension.The incidence and characteristics of the carotid arteriosclerosis plaques were compared between two groups.Then the patients were divided into three grades according to blood pressure levels,and the difference in the grades between two groups was compared.Results Statistically significant difference was showed in composition of the total plaques between two groups (OR=1.931,95% CI 1.035~3.601,χ2 =4.281,P =0.039),so was the composition of unstable plaques (OR=2.780,95% CI 1.631~4.738,χ2 =14.123,P =0.000).No significant difference was found in the composition of stable plaques between two groups (OR=1.622,χ2 =2.731,P =0.098).The grads of blood pressure levels also showed a statistically significant difference in the composition of total plaques between the two groups (ORMH =2.137,95% CI 1.723~2.65 1,χ2 =47.767,P =0.000),so was the composition of unstable plaques (ORMH =2.971, 95% CI 1.649 ~ 5.354,χ2 = 13.135,P = 0.000 ).Conclusion The incidence and characteristics of the carotid arteriosclerosis plaques are associated with type H hypertension,and they are not influenced by the blood pressure levels.