CAJ | 학술논문

目的：探讨早期双相情感障碍(BD)Ⅰ型患者脑灰质体积变化及相应异常的脑区,为早期诊断 BD 提供客观依据。方法纳入17例病程<2年的 BD I 型患者及17例正常对照,运用基于体素形态学(VBM)方法分析组间全脑灰质体积差异,统计阈值取>100个体素集合,P <0.001(未校正)。结果与对照组比较,BD 病例组左侧前扣带回背后部、左侧岛叶、右侧前扣带回膝前部、左侧颞上回、双侧海马-海马旁回-杏仁体、左侧小脑后叶灰质体积明显减小(P <0.001)。结论早期 BD 患者脑灰质表现为体积减小,主要位于双侧边缘系统、左侧颞上回及小脑皮层,可能是 BD 早期结构病理表现。
목적：탐토조기쌍상정감장애(BD)Ⅰ형환자뇌회질체적변화급상응이상적뇌구,위조기진단 BD 제공객관의거。방법납입17례병정<2년적 BD I 형환자급17례정상대조,운용기우체소형태학(VBM)방법분석조간전뇌회질체적차이,통계역치취>100개체소집합,P <0.001(미교정)。결과여대조조비교,BD 병례조좌측전구대회배후부、좌측도협、우측전구대회슬전부、좌측섭상회、쌍측해마-해마방회-행인체、좌측소뇌후협회질체적명현감소(P <0.001)。결론조기 BD 환자뇌회질표현위체적감소,주요위우쌍측변연계통、좌측섭상회급소뇌피층,가능시 BD 조기결구병리표현。
Objective To estimate brain grey matter volume changes and location of abnormal brain regions cerebrum in early stage of bipolar disorder I (BD),in order to provided objective basis for diagnosing early stages BD.Methods 1 7 cases of BD with duration less than 2 years and 1 7 normal controls were recruited in this study.The volumetric difference of grey matter between two groups were analyzed by using voxel-based morphometry(VBM)software.Statistical threshold was voxel> 100,P <0.001 (uncor-rected).Results Compared to the normal controls,the grey matter volume of BD patients decreased in the left dorcial anterior cingu-late cortex(ACC),left insular,right sub-genu ACC,left superior temporal cortex,bilateral hippocampus-parahippocampus-amydala and left posterior lobe of cerebellum(P <0.001).Conclusion The grey matter volume of early stage BD patients is decreased,main-ly locating in the bilateral limbic system,the superior temporal gyrus and the cerebellar cortex,which probably is the morphological appearance of pathomechanism in early stages of BD.