CAJ | 학술논문

目的：探讨基于脑白质疏松的血管源性轻度认知障碍(VaMCI)患者脑白质完整性的变化特点。方法对有脑白质疏松者行神经心理学评估,筛选出48例 VaMCI 患者和18例无认知障碍患者(NC 组),行 DTI 扫描测定以下两侧对称部位兴趣区的FA 值和 ADC 值：嗅内侧回白质、海马穹窿、胼胝体前部及后部、额叶下回白质、颞叶上回白质及枕叶角回白质。统计分析组间 DTI数据的差异及与神经心理评分的相关性。结果与 NC 组比较,VaMCI 组左侧额下回、左侧胼胝体前部、左侧海马穹窿及右侧角回ADC 值明显增高(P <0.05),左侧海马区 ADC 值与 MoCA 评分呈明显负相关(r=-0.34,P =0.02)。FA 值在组间无明显统计学差异(P >0.05)。结论 VaMCI 患者多个认知相关脑区的 ADC 值减低。
목적：탐토기우뇌백질소송적혈관원성경도인지장애(VaMCI)환자뇌백질완정성적변화특점。방법대유뇌백질소송자행신경심이학평고,사선출48례 VaMCI 환자화18례무인지장애환자(NC 조),행 DTI 소묘측정이하량측대칭부위흥취구적FA 치화 ADC 치：후내측회백질、해마궁륭、변지체전부급후부、액협하회백질、섭협상회백질급침협각회백질。통계분석조간 DTI수거적차이급여신경심리평분적상관성。결과여 NC 조비교,VaMCI 조좌측액하회、좌측변지체전부、좌측해마궁륭급우측각회ADC 치명현증고(P <0.05),좌측해마구 ADC 치여 MoCA 평분정명현부상관(r=-0.34,P =0.02)。FA 치재조간무명현통계학차이(P >0.05)。결론 VaMCI 환자다개인지상관뇌구적 ADC 치감저。
Objective To explore the integrity of white matter changes in patients with vascular mild cognitive impairment (VaMCI)based Leukoaraiosis.Methods The patients which appeared white matter hyperintensities in subcortical were performed psychological testing,then 48 VaMCI patients and 18 without cognitive impairment volunteers(NC)were choosed and performed DTI scanning,to determine the white matter’s values of FA and ADC in the following bilaterally symmetrical regions of interest(ROI):entorhinal cortex lobe,hippocampal vault,anterior of corpus callosum,posterior of corpus callosum,inferior frontal lobe,superior temporal lobe and angular gyrus of occipital lobe. Then the differences of the data of DTI between two groups and the relevance between neuropsychological score and DTI’s data were analysed.Results ADC values were significantly higher of VaMCI group in the left inferior frontal lobe,left anterior of corpus callo-sum,left hippocampus vault and right angular gyrus compared with NC group(P <0.05),and in the left hippocampus ADC values and MoCA scores was negatively correlated(r=-0.34,P =0.02).There was no significant difference of FA values between groups. Conclusion The ADC values in many cognitive related areas was reduced in VaMCI patients.