CAJ | 학술논문

以苯乙酮为原料进行自身羟醛缩合反应，生成1，3-二苯基-2-丁烯-1-酮，然后在BPO引发下，用NBS进行溴代，经水解后生成新型查尔酮衍生物（ Z）-1，3-二苯基-4-羟基-2-丁烯-1-酮，并采用IR、ESI-MS、1 H NMR对其结构进行了表征。考察羟醛缩合反应催化剂、温度、物料配比等因素对合成的影响。结果表明，缩合反应的较佳条件是：n（苯乙酮）：n（氯化亚砜）＝1.2：1，反应温度为室温，反应时间为30 min，缩合产物收率达72%。
이분을동위원료진행자신간철축합반응，생성1，3-이분기-2-정희-1-동，연후재BPO인발하，용NBS진행추대，경수해후생성신형사이동연생물（ Z）-1，3-이분기-4-간기-2-정희-1-동，병채용IR、ESI-MS、1 H NMR대기결구진행료표정。고찰간철축합반응최화제、온도、물료배비등인소대합성적영향。결과표명，축합반응적교가조건시：n（분을동）：n（록화아풍）＝1.2：1，반응온도위실온，반응시간위30 min，축합산물수솔체72%。
A new chalcone derivative was PrePared from acetoPhenone in the catalysis of thionyl chloride, and then in the BPO induced by bromination,hydrolyzed to generate the target Product. The structure identification was Performed by IR,ESI-MS,1 H NMR. The affecting factors of the condensation reaction were discussed so as to select the best reaction conditions. The results show that the better reaction condi-tions of the aldol condensation are as follows:n(acetoPhenone):n(SOCl2)= 1. 2:1,the reaction tem-Perature is room temPerature,the reaction time is 30 min,and the aldol reaction yield can reach 72%.