CAJ | 학술논문

制备了不同乳糖取代度的乳糖化油酰壳聚糖（ Lac-OCH）。通过粘度法检测了Lac-OCH的流变学特性；通过荧光法研究了Lac-OCH在溶液中的自聚集行为，随着乳糖取代度升高，临界聚集浓度（ CAC）值升高；采用超声法制备Lac-OCS纳米体系；采用透射电镜观察Lac-OCH纳米球呈现椭球棒状，粒径约为200 nm；研究了Lac-OCH负载药物阿霉素后的包封率和体外释放情况。
제비료불동유당취대도적유당화유선각취당（ Lac-OCH）。통과점도법검측료Lac-OCH적류변학특성；통과형광법연구료Lac-OCH재용액중적자취집행위，수착유당취대도승고，림계취집농도（ CAC）치승고；채용초성법제비Lac-OCS납미체계；채용투사전경관찰Lac-OCH납미구정현타구봉상，립경약위200 nm；연구료Lac-OCH부재약물아매소후적포봉솔화체외석방정황。
The lactose-oleoylchitosan( Lac-OCH )with different degree of substitution( DS )of lactose was PrePared. The rheological features of Lac-OCH were investigated by viscosity assay. The CAC value in-creased along with the increase of DS of lactose. The Lac-OCH nanoParticles showed dense,axiolitic tex-ture and the average diameter was aPProximate 200 nm. The sustained-release characteristics of Lac-OCH nanoParticles were studied using doxorubicin( DOX)as model drug. The results revealed the Promising Po-tential of amPhiPhilic Lac-OCH as drug carrier.