应用化工
應用化工
응용화공
APPLIED CHEMICAL INDUSTRY
2014年
7期
1181-1183,1188
,共4页
尤静%杨黎燕%余丽丽
尤靜%楊黎燕%餘麗麗
우정%양려연%여려려
β-环糊精微球%当归精油%包合率%体外释药
β-環糊精微毬%噹歸精油%包閤率%體外釋藥
β-배호정미구%당귀정유%포합솔%체외석약
β-cyclodextrin Polymer microsPheres%angelica oil%inclusion rate%drug release
采用反相乳液聚合法制备β-环糊精微球（β-CDP），饱和水溶液法包合当归精油，并研究其体外释药行为。结果表明，微球对当归精油的包合率可达75%，包合效果良好，体外释药行为符合Higuchi和Korsmeyer-PePPas模型方程，说明当归精油微球释放机制以单纯扩散为主，具有一定缓释效果，且热稳定性良好。
採用反相乳液聚閤法製備β-環糊精微毬（β-CDP），飽和水溶液法包閤噹歸精油，併研究其體外釋藥行為。結果錶明，微毬對噹歸精油的包閤率可達75%，包閤效果良好，體外釋藥行為符閤Higuchi和Korsmeyer-PePPas模型方程，說明噹歸精油微毬釋放機製以單純擴散為主，具有一定緩釋效果，且熱穩定性良好。
채용반상유액취합법제비β-배호정미구（β-CDP），포화수용액법포합당귀정유，병연구기체외석약행위。결과표명，미구대당귀정유적포합솔가체75%，포합효과량호，체외석약행위부합Higuchi화Korsmeyer-PePPas모형방정，설명당귀정유미구석방궤제이단순확산위주，구유일정완석효과，차열은정성량호。
β-Cyclodextrin Polymer microsPheres(β-CDP)were obtained by inverse emulsion Polymerization method and angelica oilβ-cyclodextrin Polymer microsPheres by saturated water solution method. The drug release behavior in vitro was studied. The result have shown that the encaPsulation efficiency was 75%. The drug release Profile could be described by Higuchi equation and Korsmeyer-PePPas equation,which indicated that the drug release mainly is simPle diffusion,and the heat stabilization is nice.
