CAJ | 학술논문

胰岛素抵抗（IR）可以定义为病理生理条件下，正常水平的胰岛素不足以使胰岛素作用的靶组织产生正常的生理效应。肥胖及身体脂肪组织的扩张可使 IR 的发生率增加。肥胖是心血管疾病和肝脏疾病发生的共同基础，常常是高脂血症和2型糖尿病发病的前奏。肥胖诱导的高游离脂肪酸（FFA）水平、炎症和氧化应激在 IR 的发生、发展中扮演重要角色。
이도소저항（IR）가이정의위병리생리조건하，정상수평적이도소불족이사이도소작용적파조직산생정상적생리효응。비반급신체지방조직적확장가사 IR 적발생솔증가。비반시심혈관질병화간장질병발생적공동기출，상상시고지혈증화2형당뇨병발병적전주。비반유도적고유리지방산（FFA）수평、염증화양화응격재 IR 적발생、발전중분연중요각색。
Insulin resistance (IR) is defined as a pathophysiological condition in which normal insulin concentration does not adequately produce a normal insulin response in target tissues.It is well established that obesity and body fat distribution are associated with the increasing rate of IR.Obesity is a common cause of cardiovascular and hepatic diseases,and often precedes the onset of hyperglycemia and predicts the development of type 2 diabetes mellitus based on IR.Free fatty acids (FFA),inflammation and oxidative stress play key roles in the development and progression of IR induced by obesity.