CAJ | 학술논문

目的：了解不同年龄段女性人乳头瘤病毒（HPV）感染状况，为宫颈癌防治提供理论依据。方法对临床3426例宫颈分泌物标本采用多通道实时荧光定量聚合酶链反应（PCR）仪检测8种高危型 HPV DNA 亚型（HPV16、18、45、31、33、52、58、67），分析不同年龄段受检者 HPV 感染状况。结果3426例标本中共检出 HPV阳性583例，阳性率为17．02％。HPV 感染人群分布以19～40岁组为主，以19～30岁人群中感染率最高，达到20．37％，明显高于其余的年龄组（P ＜0．05）。在检出类型中有单一亚型感染，也有多亚型的多重感染，其中比例最高的亚型是 HPV33/52/58/67（59．01％），明显高于其它 HPV 亚型（P ＜0．05）；居第2位和第3位的分别为HPV16（14．92％）、HPV18/45（9．43％）。结论19～30岁是女性感染 HPV 的高峰期，HPV 感染有年轻化趋势，但中老年女性群体中 HPV 感染率依然居高不下。常见的 HPV 感染基因型为33/52/58/67、16和18/45，提示有一定人群特点。
목적：료해불동년령단녀성인유두류병독（HPV）감염상황，위궁경암방치제공이론의거。방법대림상3426례궁경분비물표본채용다통도실시형광정량취합매련반응（PCR）의검측8충고위형 HPV DNA 아형（HPV16、18、45、31、33、52、58、67），분석불동년령단수검자 HPV 감염상황。결과3426례표본중공검출 HPV양성583례，양성솔위17．02％。HPV 감염인군분포이19～40세조위주，이19～30세인군중감염솔최고，체도20．37％，명현고우기여적년령조（P ＜0．05）。재검출류형중유단일아형감염，야유다아형적다중감염，기중비례최고적아형시 HPV33/52/58/67（59．01％），명현고우기타 HPV 아형（P ＜0．05）；거제2위화제3위적분별위HPV16（14．92％）、HPV18/45（9．43％）。결론19～30세시녀성감염 HPV 적고봉기，HPV 감염유년경화추세，단중노년녀성군체중 HPV 감염솔의연거고불하。상견적 HPV 감염기인형위33/52/58/67、16화18/45，제시유일정인군특점。
Objective To investigate the infection status of human papilloma virus (HPV)in women with different ages,and to provide the theory reference for preventing and treating cervical cancer.Methods Totally 3 426 samples of cervical secretions were determined for HPV DNA subtypes by multi-channel real-time fluorescence quantitation polymerase chain reaction (PCR).HPV DNA subtypes included 8 high risk types(HPV16,18,45,31,33,52,58 and 67).The infection status of HPV in women with different ages was analyzed.Results The 583 samples among the 3 426 cases were HPV positive,and the positive rate was 17.02%.HPV infection mainly distributed among women with 19-40 years old.In women with 19-30 years old,the HPV positive rate was 20.37%,which was higher than those with other ages (P <0.05).There were subtype infection and multi-subtype infection.The most common subtypes were HPV33 /52 /58 /67(59.01%),HPV16 (14.92%)and HPV18 /45 (9.43%).Conclusions The 19-30 years old is the peak period of HPV infection,but the HPV infection rate in middle aged and elder women is still high,and there is an increasing trend in young women.The most common HPV infection genotypes were HPV33 /52 /58 /67,HPV16 and HPV18 /45 with the population distribution characteristic of HPV genotype among women.