CAJ | 학술논문

目的：观察坐位下不同频率谐振对兔腰椎间盘组织病理学影响，探讨振动引起腰椎间盘病理学改变的机制。方法取90只成年健康的日本大耳白兔，随机分为5组，每组18只。 A组为正常对照组；B为造模对照组；C为4 Hz振动组；D为5 Hz振动组；E为6 Hz振动组。分别于实验第2、4、6周每组随机抽取6只白兔，取其腰5～6椎间盘组织，观察其组织形态学变化，并进行病理学评分。结果振动组整体髓核组织形态改变相对较造模对照组出现早，振动6 Hz组椎间盘组织病理学评分显著高于其他组别（P＜0．05），且随时间延长逐渐升高；振动4 Hz组与造模对照组相比无显著变化。结论振动产生动态应力易导致髓核组织病变，产生共振效应时可使椎间盘组织产生的病变程度最大。
목적：관찰좌위하불동빈솔해진대토요추간반조직병이학영향，탐토진동인기요추간반병이학개변적궤제。방법취90지성년건강적일본대이백토，수궤분위5조，매조18지。 A조위정상대조조；B위조모대조조；C위4 Hz진동조；D위5 Hz진동조；E위6 Hz진동조。분별우실험제2、4、6주매조수궤추취6지백토，취기요5～6추간반조직，관찰기조직형태학변화，병진행병이학평분。결과진동조정체수핵조직형태개변상대교조모대조조출현조，진동6 Hz조추간반조직병이학평분현저고우기타조별（P＜0．05），차수시간연장축점승고；진동4 Hz조여조모대조조상비무현저변화。결론진동산생동태응력역도치수핵조직병변，산생공진효응시가사추간반조직산생적병변정도최대。
Objective To analyze the effect of different frequency of vibration at constrained body posture on histomorphology of rabbit intervertebral discs,and to investigate the mechanism of vibration with different frequency effecting on the rabbit intervertebral discs. Methods Ninety healthy rabbits were randomly divided into 5 groups (n=18):Groups A as normal group;Groups B as control group;Groups C as 4 Hz vibration group;Groups D as 5 Hz vibration group; Groups E as 6 Hz vibration group. The L5/L6 intervertebral discs of six rabbits were extractioned on the 2nd,4th,8th week in each group randomly.Changes of intervertebral discs in histomorphology were observed at different time points,and their pathological grades were recorded. Results Pathological changes of nucleus pulposus in vibration groups were earlier than that in normal and control group , and the pathological grade in 6 Hz vibration group was obviously higher than that in other groups (P<0.05),which advanced with time. There were no significant difference between 4 Hz vibration group and control group in pathology of nucleus pulposus. Conclusion Dynamic stress caused by vibration can easily induce the harmful pathological changes of nucleus pulposus,and appearance of resonance effect will lead to a more grave destroy.