CAJ | 학술논문

目的：探讨颅内动脉瘤（intracranial aneurysm, IA)破裂介入术后应用西洛他唑对白细胞介素-6（IL-6)及丙二醛（MDA)的影响。方法选取2009年5月—2012年10月海南医学院附属医院100例 IA 破裂行介入治疗患者,按术后是否服用西洛他唑分为观察组32例和对照组68例。观察比较入院时及血管内治疗第10、20、30天两组血清 IL-6及 MDA 水平。结果观察组血清 IL-6、MDA 约术后20 d 逐渐下降至正常水平,且下降速度远大于对照组（t =7．05,P <0．05；t =6．12,P <0．05)。结论 IA 破裂介入治疗术后服用西洛他唑能有效降低全身炎症及应激反应,但其预防动脉瘤发生、再次破裂及复发的效果仍有待进一步验证。
목적：탐토로내동맥류（intracranial aneurysm, IA)파렬개입술후응용서락타서대백세포개소-6（IL-6)급병이철（MDA)적영향。방법선취2009년5월—2012년10월해남의학원부속의원100례 IA 파렬행개입치료환자,안술후시부복용서락타서분위관찰조32례화대조조68례。관찰비교입원시급혈관내치료제10、20、30천량조혈청 IL-6급 MDA 수평。결과관찰조혈청 IL-6、MDA 약술후20 d 축점하강지정상수평,차하강속도원대우대조조（t =7．05,P <0．05；t =6．12,P <0．05)。결론 IA 파렬개입치료술후복용서락타서능유효강저전신염증급응격반응,단기예방동맥류발생、재차파렬급복발적효과잉유대진일보험증。
Objective To explore the influence of Cilostazol on interleukin-6 (IL-6) and malondialdehyde (MDA) af-ter treatment of intracranial aneurysm (IA) ruptured by interventional therapy. Methods A total of 100 IA aneurysm ruptured patients undergoing interventional therapy during May 2009 and October 2012 were divided into Cilostazol treatment group (treat-ment group, n =32) and non-Cilostazol treatment group (control group, n =68). The levels of serum IL-6 and MDA in the two groups were compared on the admission day, 10th d, 20th d and 30th d after intravascular therapy. Results The levels of serum IL-6 and MDA in treatment group gradually decreased to normal 20th d after operation, and the decreased rate in treatment group was significantly higher than that in control group (t =7. 05, P <0. 05; t =6. 12, P < 0. 05). Conclusion Cilostazol medica-tion after treatment of IA ruptured by interventional therapy may effectively reduce the incidence rates of systemic inflammation and stress response, but the effect of prevention of aneurysm ruptured recurrence needs to be further studied.