CAJ | 학술논문

目的：探讨自体牙本质片修复骨缺损的临床效果。方法：选取18只2．5～3 kg新西兰兔，随机分为3组，拔取自体下切牙，制备成牙本质片，在同侧下颌骨下缘制备骨缺损，用钛钉坚固内固定牙本质片于缺损区。分别在术后1、3、6个月取材进行影像学和组织学检查。结果：术后1、3个月仍可见牙本质片与骨组织存在分界，但6个月时牙本质片完全被骨组织覆盖。放射学检查提示牙本质片与骨组织间的低密度投射影随着植入时间延长而逐渐消失，高密度影逐渐形成。组织学显示牙本质片与骨组织界面血管化，牙本质片逐渐被吸收，新骨形成。结论：坚固内固定的自体牙本质片能作为骨缺损修复材料恢复骨缺损。
목적：탐토자체아본질편수복골결손적림상효과。방법：선취18지2．5～3 kg신서란토，수궤분위3조，발취자체하절아，제비성아본질편，재동측하합골하연제비골결손，용태정견고내고정아본질편우결손구。분별재술후1、3、6개월취재진행영상학화조직학검사。결과：술후1、3개월잉가견아본질편여골조직존재분계，단6개월시아본질편완전피골조직복개。방사학검사제시아본질편여골조직간적저밀도투사영수착식입시간연장이축점소실，고밀도영축점형성。조직학현시아본질편여골조직계면혈관화，아본질편축점피흡수，신골형성。결론：견고내고정적자체아본질편능작위골결손수복재료회복골결손。
Objective:To investigate the feasibility of autogenous dentin block to repair the bone defect. Method:Autogenous grafts from freshly extracted teeth were rigidly fixed to the mandibular defects in eighteen rabbits using titanium screws in order to achieve good primary stability. Every six rabbits were stochastically sacrificed at 1,3 and 6 months after implantation respectively. For all specimens,radiographical and histological measurements were performed. Result:The boundaries of the grafts were distinctly visible in the implanted area during the first and third month. However,the teeth grafts were fully covered by new bone after sixth month. The radiograph demonstrated the progressive change in the bone and grafted tooth interface from radiolucency to radiopacity. Histologically,vascularization led to a temporary fibrous-integration in the graft-bone interface and grafts were gradually resorbed and replaced by new bone. Conclusion:Rigid fixation of auto-genous tooth dentin could serve as a novel approach for bone regeneration and to repair of bone defect.