CAJ | 학술논문

目的：探讨SCF／c－Kit信号蛋白在口腔扁平苔藓（OLP）损害组织中的表达特点及发挥的作用。方法：利用免疫组织化学方法检测30例OLP损害组织（白纹型OLP 15例，充血糜烂型OLP 15例）和10例正常口腔黏膜组织中SCF、c－Kit蛋白的表达水平，并对上述蛋白的表达与OLP患者性别、临床分型及是否伴有异常增生进行相关性分析。结果：SCF与c－Kit蛋白在OLP损害组织和正常口腔黏膜组织均有表达。与正常口腔黏膜组比较，SCF／c－Kit蛋白在OLP上皮层中表达降低，而在OLP损害组织固有层中表达升高，且两者之间的差异有统计学意义。OLP患者男性组与女性组之间、充血糜烂型OLP与白纹型OLP之间，以及病理表现无异常增生和伴有轻度异常增生组之间SCF／c－Kit蛋白的表达水平均差异无统计学意义。结论：SCF／c－Kit蛋白在OLP发病机制中可能发挥重要作用，为进一步理解OLP发病机制及治疗OLP提供了新思路。
목적：탐토SCF／c－Kit신호단백재구강편평태선（OLP）손해조직중적표체특점급발휘적작용。방법：이용면역조직화학방법검측30례OLP손해조직（백문형OLP 15례，충혈미란형OLP 15례）화10례정상구강점막조직중SCF、c－Kit단백적표체수평，병대상술단백적표체여OLP환자성별、림상분형급시부반유이상증생진행상관성분석。결과：SCF여c－Kit단백재OLP손해조직화정상구강점막조직균유표체。여정상구강점막조비교，SCF／c－Kit단백재OLP상피층중표체강저，이재OLP손해조직고유층중표체승고，차량자지간적차이유통계학의의。OLP환자남성조여녀성조지간、충혈미란형OLP여백문형OLP지간，이급병리표현무이상증생화반유경도이상증생조지간SCF／c－Kit단백적표체수평균차이무통계학의의。결론：SCF／c－Kit단백재OLP발병궤제중가능발휘중요작용，위진일보리해OLP발병궤제급치료OLP제공료신사로。
Objective:To approach the expression and its significance of stem cell factor(SCF) and its ligand,c-Kit, in oral lichen planus (OLP). Method:The expression of SCF and c-Kit in 30 OLP tissues and 10 normal mucosa tissuses was detected by immunohistochemistry. The correlation analysis was performed among the expression with patients'age,clin-ical type and the severity of pathological lesion. Result:OLP and normal mucosa tissuses both expressed SCF and c-kit. Compared with the normal,the expression of SCF and c-Kit was lower in the lamina propria,but higher in the epithelium(P<0.05). However,there was no correlation among the expression of SCF and c-Kit with the patients' age,clinical classifica-tion and the severity of pathological lesion (P >0.05). Conclusion:SCF and c-Kit may play an important effect on the de-velopment of OLP and this signal transduction pathway maybe a new target to treat OLP.