CAJ | 학술논문

目的：初步探讨联合检测干血滤纸片中促甲状腺素(TSH)及游离甲状腺素(FT4)水平筛查新生儿先天性甲状腺功能减低症(CH)的临床意义。方法对2013年6月至2013年12月出生的活产新生儿，采用时间分辨荧光免疫分析法联合检测干血滤纸片中TSH及FT4水平；对筛查阳性者再采血检测血清TSH及FT4水平，并与干血滤纸片法结果进行比较。结果共筛查新生儿31199例，确诊CH 12例，发生率1/2600，高TSH血症4例，未检测到垂体性甲状腺功能减低症。筛查确诊CH新生儿的血清TSH及FT4的检测结果与干血滤纸片检测结果一致，差异无统计学意义(P>0.05)。结论联合检测干血滤纸片中TSH及FT4水平可用于新生儿CH筛查，并有助于早期诊断与治疗，以及对中枢性CH的筛查。
목적：초보탐토연합검측간혈려지편중촉갑상선소(TSH)급유리갑상선소(FT4)수평사사신생인선천성갑상선공능감저증(CH)적림상의의。방법대2013년6월지2013년12월출생적활산신생인，채용시간분변형광면역분석법연합검측간혈려지편중TSH급FT4수평；대사사양성자재채혈검측혈청TSH급FT4수평，병여간혈려지편법결과진행비교。결과공사사신생인31199례，학진CH 12례，발생솔1/2600，고TSH혈증4례，미검측도수체성갑상선공능감저증。사사학진CH신생인적혈청TSH급FT4적검측결과여간혈려지편검측결과일치，차이무통계학의의(P>0.05)。결론연합검측간혈려지편중TSH급FT4수평가용우신생인CH사사，병유조우조기진단여치료，이급대중추성CH적사사。
Objective To explore the clinical signiifcance of combined detection of thyroid stimulating hormone (TSH) and free thyroxin (FT4) in dried blood spots in screening for congenital hypothyroidism (CH) in neonates. Methods The TSH and FT4 levels in dried blood spot were measured by time-resolved lfuorescence immunity in live born neonates from June to December 2013. If the screening was positive, the blood was drawn and the serum TSH and FT4 were measured and compared with the results from dried blood spots. Results In a total of 31 199 neonates screened, 12 cases were diagnosed with CH and the prevalence rate of CH was 1/2 600;4 cases were hyperthyropinemia and no pituitary CH was detected. There was no signiifcant difference between TSH or FT4 levels in dried blood spot and those in serum in neonates diagnosed with CH (P>0.05). Conclusions Combined detection of TSH and FT4 in dried blood spot can be used for neonatal screening of CH. It can be applied for early distinguishing CH from hyperthyropinemia, and also helpful for early diagnosis and treatment of central CH.