CAJ | 학술논문

目的：探讨谷氨酰胺预防及治疗新生儿上消化道出血的效果。方法对171例有上消化道出血高危因素的新生儿进行随机抽签分组，治疗组89例应用静脉滴注奥美拉唑加口服谷氨酰胺治疗，对照组82例应用静脉滴注奥美拉唑治疗，比较2组上消化道出血发生率和上消化道出血的止血时间。结果治疗组与对照组上消化道出血发生率差异有统计学意义（χ2＝3.917，P ﹤0.05），上消化道出血患者止血时间差异有统计学意义（ t ＝2.836，P﹤0.05）。结论口服谷氨酰胺可预防上消化道出血，并可促进上消化道出血治愈，而且是安全的。
목적：탐토곡안선알예방급치료신생인상소화도출혈적효과。방법대171례유상소화도출혈고위인소적신생인진행수궤추첨분조，치료조89례응용정맥적주오미랍서가구복곡안선알치료，대조조82례응용정맥적주오미랍서치료，비교2조상소화도출혈발생솔화상소화도출혈적지혈시간。결과치료조여대조조상소화도출혈발생솔차이유통계학의의（χ2＝3.917，P ﹤0.05），상소화도출혈환자지혈시간차이유통계학의의（ t ＝2.836，P﹤0.05）。결론구복곡안선알가예방상소화도출혈，병가촉진상소화도출혈치유，이차시안전적。
Objective To investigate the effect of glutamine on prevention and treatment of neonate upper gastrointestinal hemorrhage( UGH). Methods There were 171 neonates with risk factors for upper digestive tract hemorrhage were randomly grouped,89 cases as treatment group intravenous omeprazole and oral glutamine were given,82 cases as control group intravenous omeprazole given only. The incidence of UGH and the time of UGH between two groups were compared. Results The incidence of upper gastrointestinal bleeding in treatment group and control group showed significant difference (χ2 =3 . 917 ,P﹤0 . 05 ),gastrointestinal bleeding cases showed significant difference in hemostasia time ( t=2 . 836 ,P﹤0 . 05 ). Conclusion Oral glutamine has effect both on prevention and treatment of UGH with safety.