河北医科大学学报
河北醫科大學學報
하북의과대학학보
JOURNAL OF HEBEI MEDICAL UNIVERSITY
2014年
7期
749-752
,共4页
宋琼珠%欧阳松云%孙培宗%陈瑞英
宋瓊珠%歐暘鬆雲%孫培宗%陳瑞英
송경주%구양송운%손배종%진서영
肥胖低通气综合征%心力衰竭%连续气道正压通气
肥胖低通氣綜閤徵%心力衰竭%連續氣道正壓通氣
비반저통기종합정%심력쇠갈%련속기도정압통기
obesity hypoventilation syndrome%heart failure%continuous positive airway pressure
目的：探讨肥胖低通气综合征（ obesity hypoventilation syndrome，OHS）并发心力衰竭的有效治疗方法。方法回顾性分析120例OHS合并心力衰竭患者，无创正压通气（ noninvasive positive pressure ventilation，NPPV）组60例采用NPPV加常规抗心力衰竭药物治疗，对照组60例常规抗心力衰竭药物治疗，比较2组治疗前、治疗6个月后相关指标。结果对照组治疗后动脉血气分析、脑利钠肽（ brain natriuretic peptide，BNP）、心脏彩超、多导睡眠监测（polysomnography，PSG）均恶化（P﹤0.05或﹤0.01）。NPPV组治疗后体质量指数（body mass index，BMI）下降，动脉血气分析、BNP、心脏彩超、PSG均明显好转（ P﹤0.01）。治疗后与对照组比较，NPPV组BMI、动脉血气分析、BNP、心脏彩超、PSG均明显好转（ P﹤0.01）。结论 OHS并发心力衰竭常规抗心力衰竭疗效不佳，及早行NPPV治疗预后良好。
目的：探討肥胖低通氣綜閤徵（ obesity hypoventilation syndrome，OHS）併髮心力衰竭的有效治療方法。方法迴顧性分析120例OHS閤併心力衰竭患者，無創正壓通氣（ noninvasive positive pressure ventilation，NPPV）組60例採用NPPV加常規抗心力衰竭藥物治療，對照組60例常規抗心力衰竭藥物治療，比較2組治療前、治療6箇月後相關指標。結果對照組治療後動脈血氣分析、腦利鈉肽（ brain natriuretic peptide，BNP）、心髒綵超、多導睡眠鑑測（polysomnography，PSG）均噁化（P﹤0.05或﹤0.01）。NPPV組治療後體質量指數（body mass index，BMI）下降，動脈血氣分析、BNP、心髒綵超、PSG均明顯好轉（ P﹤0.01）。治療後與對照組比較，NPPV組BMI、動脈血氣分析、BNP、心髒綵超、PSG均明顯好轉（ P﹤0.01）。結論 OHS併髮心力衰竭常規抗心力衰竭療效不佳，及早行NPPV治療預後良好。
목적：탐토비반저통기종합정（ obesity hypoventilation syndrome，OHS）병발심력쇠갈적유효치료방법。방법회고성분석120례OHS합병심력쇠갈환자，무창정압통기（ noninvasive positive pressure ventilation，NPPV）조60례채용NPPV가상규항심력쇠갈약물치료，대조조60례상규항심력쇠갈약물치료，비교2조치료전、치료6개월후상관지표。결과대조조치료후동맥혈기분석、뇌리납태（ brain natriuretic peptide，BNP）、심장채초、다도수면감측（polysomnography，PSG）균악화（P﹤0.05혹﹤0.01）。NPPV조치료후체질량지수（body mass index，BMI）하강，동맥혈기분석、BNP、심장채초、PSG균명현호전（ P﹤0.01）。치료후여대조조비교，NPPV조BMI、동맥혈기분석、BNP、심장채초、PSG균명현호전（ P﹤0.01）。결론 OHS병발심력쇠갈상규항심력쇠갈료효불가，급조행NPPV치료예후량호。
Objective To explore effective treatments for patients with obesity hypoventilation syndrome complicated by heart failure. Methods Retrospective analysis was performed on 120 patients with obesity hypoventilation syndrome complicated by heart failure. Noninvasive positive pressure ventilation( NPPV)group(60 cases)was treated with NPPV and medications,and the control group(60 cases)only with medications. The related indicators and curative effects before treatment,6 months after treatment were compared between two groups. Results Arterial blood gas analysis,brain natriuretic peptide( BNP ),echocardiography and polysomnography( PSG ) the control group after treatment all worsened(P﹤0. 05 or ﹤0. 01). Body mass index(BMI)decreased,arterial blood gas analysis,BNP, echocardiography and PSG of NPPV group after treatment all improved significantly( P ﹤ 0 . 01 ). Compared with control group after treatment,NPPV group improved significantly in BMI,arterial blood gas analysis,BNP,echocardiography and PSG( P ﹤0. 01 ). Conclusion NPPV is an effective method for patients with obesity hypoventilation syndrome complicated by heart failure.
