CAJ | 학술논문

目的：探讨经皮置管引流(PCD)治疗重症急性胰腺炎(SAP)肠黏膜屏障功能损伤的疗效。方法按照随机数字表法将2010年4月—2013年4月收治43例 SAP 患者随机分为2组：常规保守治疗组21例(对照组)，经皮穿刺引流组22例(引流组)。动态观察两组症状和体征的缓解时间、肠道通气恢复时间、腹围及腹腔压力缓解情况、血液检验指标、APACHE-Ⅱ评分、器官衰竭情况。结果引流组腹胀的缓解时间和肠道通气恢复时间较对照组明显缩短(P <0.05)；治疗后14 d 腹围、腹内压、APACHE-Ⅱ评分、C 反应蛋白、器官衰竭发生率及持续时间均较对照组显著降低(P <0.05)。结论 PCD 可以促进 SAP 肠黏膜屏障功能损伤的恢复，以保护肠黏膜屏障功能。
목적：탐토경피치관인류(PCD)치료중증급성이선염(SAP)장점막병장공능손상적료효。방법안조수궤수자표법장2010년4월—2013년4월수치43례 SAP 환자수궤분위2조：상규보수치료조21례(대조조)，경피천자인류조22례(인류조)。동태관찰량조증상화체정적완해시간、장도통기회복시간、복위급복강압력완해정황、혈액검험지표、APACHE-Ⅱ평분、기관쇠갈정황。결과인류조복창적완해시간화장도통기회복시간교대조조명현축단(P <0.05)；치료후14 d 복위、복내압、APACHE-Ⅱ평분、C 반응단백、기관쇠갈발생솔급지속시간균교대조조현저강저(P <0.05)。결론 PCD 가이촉진 SAP 장점막병장공능손상적회복，이보호장점막병장공능。
Objective To observe the curative effect of percutaneous catheter drainage (PCD) in improvement of intestinal mucosal barrier injury of severe acute pancreatitis (SAP). Methods A total of 43 patients with SAP during April 2010 and April 2013 were randomly divided into conventional conservative treatment group (control group, n = 21) and PCD group (drainage group, n = 22) according to random number table. Remission time of symptoms and signs, re-covery time of intestinal ventilation, amelioration of abdominal perimeter and abdominal cavity pressure, hematology de-tection indexes, APACHE II score and organ failure status were dynamically observed. Results Compared with those in control group, remission time of abdominal tenderness and recovery time of intestinal ventilation were significantly short-ened (P < 0. 05); values of abdominal perimeter, abdominal cavity pressure, APACHE II scores, C-reactive protein (CRP), incidence rate and persistence time of organ failure in drainage group were significantly lower and shorter 14 d after treatment (P < 0. 05). Conclusion The method of percutaneous catheter drainage can help recovery of intestinal mucosal barrier injury of severe acute pancreatitis and protect intestinal mucosal barrier function.