CAJ | 학술논문

目的：系统评价他汀类药物能否降低感染的风险及降低感染相关死亡率。方法检索Cochrane图书馆、MEDLINE、EMBASE、PubMed、Elsevier数据库和中国生物医学文献数据库等从建库至2013年9月已完成的有关他汀的随机对照试验（至少100位参与者，持续时间至少4周）。由2位研究者按照纳入标准独立筛选文献、提取资料和评价质量后，应用Stata 12.0软件进行荟萃分析。结果纳入16个随机对照研究，共包括48973例研究对象。荟萃分析结果显示：与安慰剂组比较，他汀类药物能显著降低感染风险（OR=0.93，95%可信区间0.89-0.98，P=0.004）。但是在改善感染相关死亡率方面，两组间无显著性差异（OR=0.96，95%可信区间0.82-1.12，P=0.592）。结论他汀类药物可显著降低感染的风险，但是不能降低感染相关死亡率。
목적：계통평개타정류약물능부강저감염적풍험급강저감염상관사망솔。방법검색Cochrane도서관、MEDLINE、EMBASE、PubMed、Elsevier수거고화중국생물의학문헌수거고등종건고지2013년9월이완성적유관타정적수궤대조시험（지소100위삼여자，지속시간지소4주）。유2위연구자안조납입표준독립사선문헌、제취자료화평개질량후，응용Stata 12.0연건진행회췌분석。결과납입16개수궤대조연구，공포괄48973례연구대상。회췌분석결과현시：여안위제조비교，타정류약물능현저강저감염풍험（OR=0.93，95%가신구간0.89-0.98，P=0.004）。단시재개선감염상관사망솔방면，량조간무현저성차이（OR=0.96，95%가신구간0.82-1.12，P=0.592）。결론타정류약물가현저강저감염적풍험，단시불능강저감염상관사망솔。
Objective To systematically review whether statins can reduce the risk of infection and infection-related mortality. Methods We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software. Results Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592). Conclusion Statins can significantly reduce the risk of infection but does not lower infection-related mortality.