CAJ | 학술논문

目的：探讨青少年痤疮患者雄激素受体（A R ）水平的变化情况以及患者雄激素受体基因CAG多态性的分布情况。方法选择100例（其中男性50例、女性50例）面部明显痤疮在校高中生作为观察组，再按照1∶1匹配原则选择100例面部无痤疮的在校高中生作为对照组，检查患者外周血雄激素水平、白细胞雄激素受体（AR）以及雄激素受体基因CAG多态性。结果男性和女性痤疮患者其血浆睾酮水平、AR水平比正常对照组均升高，差异具有统计学意义（P＜0．05）；随着男性痤疮患者其痤疮越严重，其血浆睾酮有所升高，但是差异不具有统计学意义（P＞0．05），而不同程度女性痤疮患者其血浆睾酮水平具有统计学意义（P＜0．05）；随着痤疮患者其痤疮越严重，AR水平有所升高，差异具有统计学意义（P＜0．05）；痤疮患者携带CAG短片段的比例显著高于对照组携带比例（P＜0．05）。结论痤疮发生与发展过程中，雄激素以及雄激素受体增高起着重要的作用，特别对于女性痤疮患者而言，其影响更为显著；携带雄激素受体基因CAG短片段的人群，其患痤疮的危险性更大。
목적：탐토청소년좌창환자웅격소수체（A R ）수평적변화정황이급환자웅격소수체기인CAG다태성적분포정황。방법선택100례（기중남성50례、녀성50례）면부명현좌창재교고중생작위관찰조，재안조1∶1필배원칙선택100례면부무좌창적재교고중생작위대조조，검사환자외주혈웅격소수평、백세포웅격소수체（AR）이급웅격소수체기인CAG다태성。결과남성화녀성좌창환자기혈장고동수평、AR수평비정상대조조균승고，차이구유통계학의의（P＜0．05）；수착남성좌창환자기좌창월엄중，기혈장고동유소승고，단시차이불구유통계학의의（P＞0．05），이불동정도녀성좌창환자기혈장고동수평구유통계학의의（P＜0．05）；수착좌창환자기좌창월엄중，AR수평유소승고，차이구유통계학의의（P＜0．05）；좌창환자휴대CAG단편단적비례현저고우대조조휴대비례（P＜0．05）。결론좌창발생여발전과정중，웅격소이급웅격소수체증고기착중요적작용，특별대우녀성좌창환자이언，기영향경위현저；휴대웅격소수체기인CAG단편단적인군，기환좌창적위험성경대。
Objective To investigate the adolescent patients with acne androgen receptor (AR) levels and the distribution of androgen receptor gene CAG polymorphism .Methods 100 cases (inclu-ding 50 male and 50 female) the obvious facial acne high school student as the observation group ,1∶1 according to the matching principle to select 100 cases of facial acne free high school students as the control group .Patients were examined for peripheral androgen levels ,androgen receptor (AR) and androgen receptor gene CAG polymorphism .Results The male and female patients with acne and the plasma levels of testosterone ,AR levels were higher than the normal control group ,there were statis-tically significant differences (P<0 .05) .With the male patients with acne was more serious ,the plas-ma testosterone increased ,but there were no statistically significant differences (P>0 .05) ,and in pa-tients with different degree of plasma testosterone of female acne the level of statistical significance (P<0 .05) .Along with the more serious acne patients ,the level of AR increased ,there were statistically significant differences (P<0 .05) .Acne patients carrying the CAG short fragments of proportion sig-nificantly higher than control group (P<0 .05)carrying ratio .Conclusion The development process and the occurrence of acne ,androgen and androgen receptor increased plays an important role ,especially for female patients with acne ,the effect is more remarkable .With the androgen receptor gene CAG short fragments of the crowd ,the acne is more dangerous .