CAJ | 학술논문

目的：观察生长激素释放肽(growth hormone releasing peptide，Ghrelin)和基质金属蛋白酶-9（Matrix metalloproteinases，MMP-9）在结直肠癌组织中的表达水平及意义。方法：应用免疫组织化学方法检测Ghrelin和MMP-9在67例结直肠癌组织及62例癌旁正常黏膜组织中的表达，分析Ghrelin和MMP-9与结直肠癌临床病理特征的关系及两者的相关性。结果：Ghrelin在结直肠癌组织中的阳性表达率为59.70%，高于癌旁正常黏膜组织（24.39%，P＜0.05）；MMP-9在结直肠癌组织中的阳性表达率为83.58%，显著高于癌旁正常黏膜组织（18.39%，P＜0.05）；Ghrelin和MMP-9的高表达与肿瘤浸润深度、分化程度、淋巴结转移和肝转移相关（P＜0.05）；Ghrelin与MMP-9的阳性表达呈正相关（κ=0.832，P＜0.001）。结论：Ghrelin和MMP-9表达升高可能与结直肠癌的恶性程度相关，联合检测Ghrelin和MMP-9可能对结直肠癌恶性程度及患者预后评估具有重要意义。
목적：관찰생장격소석방태(growth hormone releasing peptide，Ghrelin)화기질금속단백매-9（Matrix metalloproteinases，MMP-9）재결직장암조직중적표체수평급의의。방법：응용면역조직화학방법검측Ghrelin화MMP-9재67례결직장암조직급62례암방정상점막조직중적표체，분석Ghrelin화MMP-9여결직장암림상병리특정적관계급량자적상관성。결과：Ghrelin재결직장암조직중적양성표체솔위59.70%，고우암방정상점막조직（24.39%，P＜0.05）；MMP-9재결직장암조직중적양성표체솔위83.58%，현저고우암방정상점막조직（18.39%，P＜0.05）；Ghrelin화MMP-9적고표체여종류침윤심도、분화정도、림파결전이화간전이상관（P＜0.05）；Ghrelin여MMP-9적양성표체정정상관（κ=0.832，P＜0.001）。결론：Ghrelin화MMP-9표체승고가능여결직장암적악성정도상관，연합검측Ghrelin화MMP-9가능대결직장암악성정도급환자예후평고구유중요의의。
Objective:To investigate the correlation between the Ghrelin and MMP -9 in colorectal cancer tissue. Methods:Immunohistochemical staining was performed to detect the expression of Ghrelin and MMP-9 in the tumor tissues of 67 patients and in the adjacent mucosal tissues of 62 cases. And statistical analysis technique was used to investigate the relation between their expression and the clinicopathologic parameters of the patients, and the relationship between the expression of Ghrelin and MMP-9. Results:The total positive rate of Ghrelin expression in the carcinoma tissues was 59.70%, significantly highter than that in the adjacent mucosal tissues(24.39%,P<0.05). The positive rate of MMP-9 expression in the carcinoma tissues was 83.58%, significantly highter than that in the adjacent mucosal tissues(18.39%,P<0.05). The expression of Ghrelin and MMP-9 were significantly correlated with invasion depth, differentiation, lymph node metastasis and hepatic metastasis (P<0.05). The positive expression of Ghrelin was consistent with the positive expression of MMP-9 (κ=0.832,P<0.001). Conclusion:Expressions of Ghrelin and MMP-9 are closely related to the degree of malignancy of colorectal cancer, and their combination may be an important indicator to evaluate the malignant degree and prognosis of the colorectal cancer.