湖北农业科学
湖北農業科學
호북농업과학
2014年
10期
2233-2237,2243
,共6页
表观遗传%序列依赖性%转录起始位点(TSS)%核小体定位
錶觀遺傳%序列依賴性%轉錄起始位點(TSS)%覈小體定位
표관유전%서렬의뢰성%전록기시위점(TSS)%핵소체정위
epigenetic%DNA sequence-dependent%TSS%nucleosome mapping
核小体定位是参与真核生物基因表达调控的一种重要的表观遗传因素，深刻影响基因转录、DNA复制与修复等生物学过程。对于在许多基因位点，比如转录起始位点（TSS)、转录因子结合位点（TFBS)等处的核小体定位已有不少报道。主要介绍了核小体的定位特性，综述了转录起始位点处核小体的定位特征，分别从序列依赖性因素和DNA甲基化、组蛋白变体及修饰、染色质重塑、可变剪接等表观遗传因素较为详细地概括了转录起始位点核小体定位的研究进展。
覈小體定位是參與真覈生物基因錶達調控的一種重要的錶觀遺傳因素，深刻影響基因轉錄、DNA複製與脩複等生物學過程。對于在許多基因位點，比如轉錄起始位點（TSS)、轉錄因子結閤位點（TFBS)等處的覈小體定位已有不少報道。主要介紹瞭覈小體的定位特性，綜述瞭轉錄起始位點處覈小體的定位特徵，分彆從序列依賴性因素和DNA甲基化、組蛋白變體及脩飾、染色質重塑、可變剪接等錶觀遺傳因素較為詳細地概括瞭轉錄起始位點覈小體定位的研究進展。
핵소체정위시삼여진핵생물기인표체조공적일충중요적표관유전인소，심각영향기인전록、DNA복제여수복등생물학과정。대우재허다기인위점，비여전록기시위점（TSS)、전록인자결합위점（TFBS)등처적핵소체정위이유불소보도。주요개소료핵소체적정위특성，종술료전록기시위점처핵소체적정위특정，분별종서렬의뢰성인소화DNA갑기화、조단백변체급수식、염색질중소、가변전접등표관유전인소교위상세지개괄료전록기시위점핵소체정위적연구진전。
Nucleosome mapping,an important epigenetic factor participating in regulating eukaryotic gene expression, deeply affects lots of biological processes,including gene transcription,DNA replication,DNA repair and so forth. The nucleosome mapping around TSS and TFBS has been reported properties of nucleosome mapping were introduced in this paper. Features in nucleosome mapping around TSS were summarized. Advances on nucleosome mapping around TSS from both the DNA sequence-dependent factor and some epigenetic factors including DNA methylation, variants and modification of histone, chromation remodeling,alternative splicing were reviewed.
