CAJ | 학술논문

目的：探讨老年期血管性抑郁的临床与影像学特点。方法：回顾性分析经汉密尔顿抑郁量表评分的26例老年期血管性抑郁患者的临床资料。结果：老年期血管性抑郁患者汉密尔顿抑郁量表总分与对照组无明显差异。因子分中，焦虑/躯体化、体重减轻及睡眠障碍也无明显差异；认知障碍与阻滞显著高于对照组，日夜变化与绝望感显著低于对照组。患者颅脑 MRI 主要显示额叶与基底节腔隙梗塞及/或脑室周围缺血性脱髓鞘。结论：老年期血管性抑郁的临床特点是迟滞突出，激越不明显；认知障碍常见，绝望感较轻；日夜变化小，病情波动大。影像学所见提示主要病损在基底节-额叶的脑内情感调节通路。
목적：탐토노년기혈관성억욱적림상여영상학특점。방법：회고성분석경한밀이돈억욱량표평분적26례노년기혈관성억욱환자적림상자료。결과：노년기혈관성억욱환자한밀이돈억욱량표총분여대조조무명현차이。인자분중，초필/구체화、체중감경급수면장애야무명현차이；인지장애여조체현저고우대조조，일야변화여절망감현저저우대조조。환자로뇌 MRI 주요현시액협여기저절강극경새급/혹뇌실주위결혈성탈수초。결론：노년기혈관성억욱적림상특점시지체돌출，격월불명현；인지장애상견，절망감교경；일야변화소，병정파동대。영상학소견제시주요병손재기저절-액협적뇌내정감조절통로。
Objective:To explore the clinical and imaging features of senile vascular depressions. Methods:The clinical data of 26 patients with senile vascular depressions evaluated by the Hamilton depression scale(HAMD) were retrospectively analyzed. Re-sults: Between treatment group and control group, there was no significant difference in HAMD total score, however, there were signif-icant differences in anxiety/ somatization, wight loss and sleep disorder scores. The cognitive disorder and retardation scores of treat-ment group were significantly higher than those of control group, however, the day/ night change and hopelessness were obviously lower than those of control group. The patients' craniocerebral MRI mainly showed lacunar infarction in frontal lobe and basal nucleus and/ or peri-ventricular ischemic demyelination. Conclusions: The clinical features of senile vascular depressions are: retardation is promi-nent, agitation is not obvious, cognition disorders are common, hopelessness is mild, day/ night change is small and illness state fluc-tuates largely; and the main lesion showed by the imaging is in the intracerebral emotional adjustment pathway in frontal lobe and basal nucleus.