广东医学
廣東醫學
엄동의학
GUNAGDONG MEDICAL JOURNAL
2014年
11期
1673-1676
,共4页
鼻咽癌%放射治疗%调强放射治疗%容积旋转调强治疗%剂量学
鼻嚥癌%放射治療%調彊放射治療%容積鏇轉調彊治療%劑量學
비인암%방사치료%조강방사치료%용적선전조강치료%제량학
nasopharyngeal carcinoma%radiotherapy%intensity modulated radiotherapy%volumetric modulated arc therapy%dosimtrics
目的:探讨常规调强放射治疗(IMRT)7野、9野及容积旋转调强治疗(VMAT)三种不同布野方案在鼻咽癌(Ⅰ~Ⅲ期)治疗中的剂量学特点及治疗效率。方法用 Eclipse 治疗计划系统对12例鼻咽癌患者(Ⅰ~Ⅲ期)分别用 IMRT 7野(A 组)、9野(B 组)及 VMAT(C 组)进行计划设计治疗,比较3组的肿瘤靶区剂量分布、危及器官的剂量和治疗时间。结果3组的剂量分布均能满足临床剂量要求,虽然在肿瘤靶区覆盖性、靶区适形度(CI)及靶区均匀性(HI)上差异无统计学意义(P >0.05),但 C 组的 HI 较高。在危及器官受量方面,3组对危及器官的保护均符合临床要求。在治疗时间方面,C 组的机器跳数及治疗时间较 A、B 组显著的缩短(P <0.001)。结论3种布野计划在Ⅰ~Ⅲ期鼻咽癌治疗中的剂量学均可满足临床要求。VMAT 有更好的治疗效率,应优先考虑。对于 IMRT 7野和9野应当视危及器官保护和靶区范围具体情况而进行选择。
目的:探討常規調彊放射治療(IMRT)7野、9野及容積鏇轉調彊治療(VMAT)三種不同佈野方案在鼻嚥癌(Ⅰ~Ⅲ期)治療中的劑量學特點及治療效率。方法用 Eclipse 治療計劃繫統對12例鼻嚥癌患者(Ⅰ~Ⅲ期)分彆用 IMRT 7野(A 組)、9野(B 組)及 VMAT(C 組)進行計劃設計治療,比較3組的腫瘤靶區劑量分佈、危及器官的劑量和治療時間。結果3組的劑量分佈均能滿足臨床劑量要求,雖然在腫瘤靶區覆蓋性、靶區適形度(CI)及靶區均勻性(HI)上差異無統計學意義(P >0.05),但 C 組的 HI 較高。在危及器官受量方麵,3組對危及器官的保護均符閤臨床要求。在治療時間方麵,C 組的機器跳數及治療時間較 A、B 組顯著的縮短(P <0.001)。結論3種佈野計劃在Ⅰ~Ⅲ期鼻嚥癌治療中的劑量學均可滿足臨床要求。VMAT 有更好的治療效率,應優先攷慮。對于 IMRT 7野和9野應噹視危及器官保護和靶區範圍具體情況而進行選擇。
목적:탐토상규조강방사치료(IMRT)7야、9야급용적선전조강치료(VMAT)삼충불동포야방안재비인암(Ⅰ~Ⅲ기)치료중적제량학특점급치료효솔。방법용 Eclipse 치료계화계통대12례비인암환자(Ⅰ~Ⅲ기)분별용 IMRT 7야(A 조)、9야(B 조)급 VMAT(C 조)진행계화설계치료,비교3조적종류파구제량분포、위급기관적제량화치료시간。결과3조적제량분포균능만족림상제량요구,수연재종류파구복개성、파구괄형도(CI)급파구균균성(HI)상차이무통계학의의(P >0.05),단 C 조적 HI 교고。재위급기관수량방면,3조대위급기관적보호균부합림상요구。재치료시간방면,C 조적궤기도수급치료시간교 A、B 조현저적축단(P <0.001)。결론3충포야계화재Ⅰ~Ⅲ기비인암치료중적제량학균가만족림상요구。VMAT 유경호적치료효솔,응우선고필。대우 IMRT 7야화9야응당시위급기관보호화파구범위구체정황이진행선택。
Objective To compare step - and - shoot intensity modulated radiation therapy(IMRT)of 7 or 9 beam with volume modulate arc therapy(VMAT)for nasopharyngeal carcinoma(NPC,Phase Ⅰ - Ⅲ)patients with re-gard to the sparing effect on dosimetic quality and efficiency of delivery. Methods Twelve patients who diagnosed with NPC were treated with IMRT 7 beam,9 beam and VMAT by the eclipse planning system. Dosimetric comparisons among these 3 plans were analyzed including sparing of PTV,sparing of OARs and delivery time. Results All the 3 plans can meet the clinical dosimetric requirements. There was no significant difference in coverage,homogeneity(HI)or conformity (CI)of PTV among all the 3 plans. The protections of OARs in all the 3 plans were consistent with clinical requirement. However,significant lower machine hops and shorter delivery time were revealed in VMAT. Conclusion Our results in-dicate that all 3 therapy plans could meet the clinical dosimetric requirements for the NPC(Phase Ⅰ - Ⅲ),but VMAT provides better treatment efficiency. The choice between IMRT 7 and 9 beam shall be considered according to the protec-tion of OARs and general condition.