CAJ | 학술논문

目的：探讨超敏C-反应蛋白（hs-CRP）在早产儿感染性疾病（ID）诊断中的应用价值。方法对2012年1月至2013年12月在我院就诊的162例早产儿的临床资料行回顾性分析，根据有无疾病及感染与否分为3组，ID组（n＝46），NID组（n＝66），对照组（n＝50），比较治疗前后的hs-CRP、血细胞参数（WBC、PLT、NGR%、ESR）、感染阳性检出率及不同病原体hs-CRP水平。结果（1）3组一般资料组间比较差异均无统计学意义（P＞0.05）。（2）ID组的hs-CRP阳性检出率明显高于WBC，而 NID组的WBC阳性检出率明显高于hs-CRP，差异均有统计学意义（P＜0.05）。（3）较之病毒、支原体等其他病原体，细菌感染的 hs-CRP 水平明显高，差异有统计学意义（P＜0.05），而G+菌与G-菌感染比较，hs-CRP水平差异无统计学意义（P＞0.05）。（4）组内比较：较之治疗前，ID组治疗后的hs-CRP、WBC、NGR%、ESR，NID组的hs-CRP、WBC均明显下降，差异有统计学意义（P＜0.05）；ID组的PLT，NID组的PLT、NGR%、ESR，对照组各指标，差异均无统计学意义（P＞0.05）。组间比较：治疗前，ID组、NID组的hs-CRP、WBC明显高于对照组， ID组的NGR%、ESR明显高于NID组、对照组，差异均有统计学意义（P＜0.05）；NID组与对照组的NGR%、ESR，各组的PLT以及治疗后各组指标间，差异均无统计学意义（P＞0.05）。结论 hs-CRP虽可作为早产儿ID，尤其是细菌感染的早期诊断指标，但实际应用中仍需结合临床表现以及其他非特异性指标，以提高诊断准确率。
목적：탐토초민C-반응단백（hs-CRP）재조산인감염성질병（ID）진단중적응용개치。방법대2012년1월지2013년12월재아원취진적162례조산인적림상자료행회고성분석，근거유무질병급감염여부분위3조，ID조（n＝46），NID조（n＝66），대조조（n＝50），비교치료전후적hs-CRP、혈세포삼수（WBC、PLT、NGR%、ESR）、감염양성검출솔급불동병원체hs-CRP수평。결과（1）3조일반자료조간비교차이균무통계학의의（P＞0.05）。（2）ID조적hs-CRP양성검출솔명현고우WBC，이 NID조적WBC양성검출솔명현고우hs-CRP，차이균유통계학의의（P＜0.05）。（3）교지병독、지원체등기타병원체，세균감염적 hs-CRP 수평명현고，차이유통계학의의（P＜0.05），이G+균여G-균감염비교，hs-CRP수평차이무통계학의의（P＞0.05）。（4）조내비교：교지치료전，ID조치료후적hs-CRP、WBC、NGR%、ESR，NID조적hs-CRP、WBC균명현하강，차이유통계학의의（P＜0.05）；ID조적PLT，NID조적PLT、NGR%、ESR，대조조각지표，차이균무통계학의의（P＞0.05）。조간비교：치료전，ID조、NID조적hs-CRP、WBC명현고우대조조， ID조적NGR%、ESR명현고우NID조、대조조，차이균유통계학의의（P＜0.05）；NID조여대조조적NGR%、ESR，각조적PLT이급치료후각조지표간，차이균무통계학의의（P＞0.05）。결론 hs-CRP수가작위조산인ID，우기시세균감염적조기진단지표，단실제응용중잉수결합림상표현이급기타비특이성지표，이제고진단준학솔。
ObjectiveTo observe the clinical value of high sensitivity C-reactive protein (hs-CRP) on the diagnosis of infectious diseases (ID) in premature infants.MethodsThe clinical materials of 162 cases were reviewed and analyzed from Jun. 2012 to Dec. 2013. They could be divided into three groups including the ID group (n=46), NID group (n=66), and control group by the disease and infection or not to compare the hs-CRP, blood cell parameters (WBC, PLT, NGR%, ESR), positive rate of infection and level of hs-CRP in different pathogens.Results(1) There were no significant differences by the general data between the three groups (P>0.05). (2) The positive detection rate of the hs-CRP in the ID group was significantly higher than the WBC, and the positive detection rate of the WBC in the NID group was significantly higher than the hs-CRP. There were significant differences between them (P<0.05). (3) The level of hs-CRP with bacterial infection was significantly higher than the other pathogens' (P<0.05). There were no significant differences between the G+ bacteria and G- bacteria's (P>0.05). (4) Compared with pretherapy, the hs-CRP, WBC, NGR% and ESR in the ID group, and the hs-CRP, WBC in the NID group were significantly decreased after treatment. There were significant differences between them (P<0.05). There were no significant differences between the PLT in the ID group, PLT, NGR%, ESR in the NID group, and each index in the control group (P>0.05). The hs-CRP, WBC in the ID and NID groups were significantly higher then the control group, and the NGR%, ESR in the ID group were significantly higher then the NID and control group in pretherapy (P<0.05). There were no significant differences between the NGR%, ESR in the NID and control group, each group’ s PLT, and each index after treatment (P>0.05).ConclusionAlthough hs-CRP can be used as the newborn ID, especially early diagnosis index of bacterial infection, but in practical application we need to combine the clinical manifestations and other nonspecific index for improving the accuracy rate of diagnosis.