中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
13期
2416-2419
,共4页
彭蕾%叶珺%郜玉峰%邹桂舟
彭蕾%葉珺%郜玉峰%鄒桂舟
팽뢰%협군%고옥봉%추계주
血浆置换%肝炎,慢性%治疗结果%重型肝炎
血漿置換%肝炎,慢性%治療結果%重型肝炎
혈장치환%간염,만성%치료결과%중형간염
Plasma exchange%Hepatitis,chronic%Treatment outcome%Severe hepatitis
目的：探讨人工肝血浆置换治疗对慢性重型肝炎的临床疗效。方法选取我院肝病科行人工肝血浆置换治疗的慢性重型肝炎患者67例为研究对象，比较治疗前后患者血常规及肝功能等生化学指标的变化，评价血浆置换的疗效。结果67例重型肝炎患者经过人工肝血浆置换治疗后，白细胞、肝功能、凝血功能等指标及临床症状均得到不同程度的改善。其中，白细胞、直接胆红素在治疗前后差异有统计学意义（t＝2.42、2.51，P＜0.05），且ALT、AST、PT以及总胆红素的差异尤为显著（t分别为3.58、2.97、4.23及5.25；P均＜0.01）。慢性重型肝炎早、中、晚期治疗有效率（包括治愈和好转）分别为86%、57%、11%；早期、中期与晚期重型肝炎患者PE治疗相比，治疗有效率的差异有统计学意义（χ2＝18.53，P＜0.01）。结论应用人工肝血浆置换治疗慢性重型肝炎是目前比较成熟的肝脏替代疗法，具有一定疗效，尤其对早、中期的患者疗效更佳。
目的：探討人工肝血漿置換治療對慢性重型肝炎的臨床療效。方法選取我院肝病科行人工肝血漿置換治療的慢性重型肝炎患者67例為研究對象，比較治療前後患者血常規及肝功能等生化學指標的變化，評價血漿置換的療效。結果67例重型肝炎患者經過人工肝血漿置換治療後，白細胞、肝功能、凝血功能等指標及臨床癥狀均得到不同程度的改善。其中，白細胞、直接膽紅素在治療前後差異有統計學意義（t＝2.42、2.51，P＜0.05），且ALT、AST、PT以及總膽紅素的差異尤為顯著（t分彆為3.58、2.97、4.23及5.25；P均＜0.01）。慢性重型肝炎早、中、晚期治療有效率（包括治愈和好轉）分彆為86%、57%、11%；早期、中期與晚期重型肝炎患者PE治療相比，治療有效率的差異有統計學意義（χ2＝18.53，P＜0.01）。結論應用人工肝血漿置換治療慢性重型肝炎是目前比較成熟的肝髒替代療法，具有一定療效，尤其對早、中期的患者療效更佳。
목적：탐토인공간혈장치환치료대만성중형간염적림상료효。방법선취아원간병과행인공간혈장치환치료적만성중형간염환자67례위연구대상，비교치료전후환자혈상규급간공능등생화학지표적변화，평개혈장치환적료효。결과67례중형간염환자경과인공간혈장치환치료후，백세포、간공능、응혈공능등지표급림상증상균득도불동정도적개선。기중，백세포、직접담홍소재치료전후차이유통계학의의（t＝2.42、2.51，P＜0.05），차ALT、AST、PT이급총담홍소적차이우위현저（t분별위3.58、2.97、4.23급5.25；P균＜0.01）。만성중형간염조、중、만기치료유효솔（포괄치유화호전）분별위86%、57%、11%；조기、중기여만기중형간염환자PE치료상비，치료유효솔적차이유통계학의의（χ2＝18.53，P＜0.01）。결론응용인공간혈장치환치료만성중형간염시목전비교성숙적간장체대요법，구유일정료효，우기대조、중기적환자료효경가。
Objective To investigate the clinical effect on the treatment of chronic severe hepatitis with artificial liver plasma exchange.Methods A total of 67 patients with severe hepatitis at early, middle and late stages received treatment of Artificial Liver Support System. Pre- and post-therapy liver function, blood routine test, PTA, PT were analyzed, and symptoms of all patients were observed. Results After the treatment of plasma exchange, liver function, PTA, PT and blood routine of patients improved. Among them, white blood cells, direct bilirubin have statistical significance before and after treatment (t=2.42, 2.51,P<0.05), particularly ALT, AST, PT, and bilirubin were significantly different (t were 3.58, 2.97, 4.23 and 5.25;P<0.01). The effective rates of patients with chronic severe hepatitis at early, middle and late stages were 86%, 57% and 11% respectively;compared to the early, middle and late stage PE patients with severe hepatitis treatment, the difference was statistically significant for efficient (χ2=18.53,P<0.01).Conclusion Application of artificial liver plasma exchange in the treatment of chronic severe hepatitis is a relatively mature liver replacement therapy, has certain curative effect, especially on the early, mid patients with better effect.
