中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
13期
2408-2411
,共4页
康从利%王艳%林雪%徐风亮
康從利%王豔%林雪%徐風亮
강종리%왕염%림설%서풍량
肝肿瘤%肿瘤标记,生物学%诊断%联合检测
肝腫瘤%腫瘤標記,生物學%診斷%聯閤檢測
간종류%종류표기,생물학%진단%연합검측
Liver neoplasms%Tumor markers,biological%Diagnosis%Combined detection
目的：探讨血清肿瘤标记物甲胎蛋白（AFP）、α-L-岩藻糖苷酶（AFU）、糖类抗原199（CA199）、高尔基体膜蛋白73（GP73）联合检测诊断原发性肝癌的临床应用价值。方法采用电化学发光法和全自动生化分析仪分别检测125例原发性肝癌患者（恶性肿瘤组）治疗前及治疗后3个月血清AFP、AFU、CA199、GP73水平，与50例肝硬化患者（良性对照组）及50例健康体检者（健康对照组）对照，采用回顾性统计方法分析AFP、AFU、CA199、GP73联合检测在原发性肝癌早期诊断及监控治疗中的临床应用价值。结果（1）原发性肝癌患者血清 AFP、AFU、CA199、GP73水平显著高于良性对照组和健康对照组（P＜0.01）；（2）原发性肝癌患者血清肿瘤标记物水平与肿瘤分化程度、腹水、肝硬化、复发、转移明显相关（P＜0.05）；（3）原发性肝癌患者治疗3个月后血清肿瘤标记物水平较治疗前明显下降（P＜0.01）；（4）四项肿瘤标记物联合检测诊断原发性肝癌的敏感性、准确性、阴性预测值分别达到96.00%、93.71%、89.80%，与各单项检测比较差异有统计学意义（P＜0.05）。结论血清肿瘤标记物 AFP、AFU、CA199、GP73联合动态检测能够有效提高原发性肝癌的早期诊断率，减少误漏诊，并对判断肿瘤分化程度、复发转移及预后观察具有较高的临床应用价值。
目的：探討血清腫瘤標記物甲胎蛋白（AFP）、α-L-巖藻糖苷酶（AFU）、糖類抗原199（CA199）、高爾基體膜蛋白73（GP73）聯閤檢測診斷原髮性肝癌的臨床應用價值。方法採用電化學髮光法和全自動生化分析儀分彆檢測125例原髮性肝癌患者（噁性腫瘤組）治療前及治療後3箇月血清AFP、AFU、CA199、GP73水平，與50例肝硬化患者（良性對照組）及50例健康體檢者（健康對照組）對照，採用迴顧性統計方法分析AFP、AFU、CA199、GP73聯閤檢測在原髮性肝癌早期診斷及鑑控治療中的臨床應用價值。結果（1）原髮性肝癌患者血清 AFP、AFU、CA199、GP73水平顯著高于良性對照組和健康對照組（P＜0.01）；（2）原髮性肝癌患者血清腫瘤標記物水平與腫瘤分化程度、腹水、肝硬化、複髮、轉移明顯相關（P＜0.05）；（3）原髮性肝癌患者治療3箇月後血清腫瘤標記物水平較治療前明顯下降（P＜0.01）；（4）四項腫瘤標記物聯閤檢測診斷原髮性肝癌的敏感性、準確性、陰性預測值分彆達到96.00%、93.71%、89.80%，與各單項檢測比較差異有統計學意義（P＜0.05）。結論血清腫瘤標記物 AFP、AFU、CA199、GP73聯閤動態檢測能夠有效提高原髮性肝癌的早期診斷率，減少誤漏診，併對判斷腫瘤分化程度、複髮轉移及預後觀察具有較高的臨床應用價值。
목적：탐토혈청종류표기물갑태단백（AFP）、α-L-암조당감매（AFU）、당류항원199（CA199）、고이기체막단백73（GP73）연합검측진단원발성간암적림상응용개치。방법채용전화학발광법화전자동생화분석의분별검측125례원발성간암환자（악성종류조）치료전급치료후3개월혈청AFP、AFU、CA199、GP73수평，여50례간경화환자（량성대조조）급50례건강체검자（건강대조조）대조，채용회고성통계방법분석AFP、AFU、CA199、GP73연합검측재원발성간암조기진단급감공치료중적림상응용개치。결과（1）원발성간암환자혈청 AFP、AFU、CA199、GP73수평현저고우량성대조조화건강대조조（P＜0.01）；（2）원발성간암환자혈청종류표기물수평여종류분화정도、복수、간경화、복발、전이명현상관（P＜0.05）；（3）원발성간암환자치료3개월후혈청종류표기물수평교치료전명현하강（P＜0.01）；（4）사항종류표기물연합검측진단원발성간암적민감성、준학성、음성예측치분별체도96.00%、93.71%、89.80%，여각단항검측비교차이유통계학의의（P＜0.05）。결론혈청종류표기물 AFP、AFU、CA199、GP73연합동태검측능구유효제고원발성간암적조기진단솔，감소오루진，병대판단종류분화정도、복발전이급예후관찰구유교고적림상응용개치。
Objective To study the clinical value of serum tumor markers, such as alpha fetoprotein(AFP), Alpha L-fucus glycosidase(AFU), carbohydrate antigen 199(CA199), Golgi membrane protein 73(GP73), in the diagnosis of primary liver cancer with combined detection method.Methods 125 patients with primary liver cancer were studied as a malignant tumor group, the level of serum tumor markers (AFP, AFU, CA199, GP73) was analyzed with electrochemical luminescence and fully automatic biochemical analyzer before treatment and after 3 months treatment respectively. Fifty patients with liver benign lesions and 50 healthy peoples were set as control groups. The serum tumor markers were statistical analysis retrospectively.Results (1)The level of serum tumor markers (AFP, AFU, CA199, GP73) in the patients with primary liver cancer were higher obviously than the other two groups(P<0.01). (2)The level of serum tumor markers in the patients with primary liver cancer had close correlations with tumor differentiation degree, ascitic fluid, cirrhosis of the liver, recurrence and metastasis(P<0.05). (3)The level of serum tumor markers after treatment were lower significantly than prior treatment(P<0.01). (4)By the combined detection of the four serum tumor markers in patients with primary liver cancer, the sensitivity, accuracy, negative predictive value reached 96.00%, 93.71%, 89.80%, respectively. It also had significant difference compared with single detection(P<0.05).ConclusionThe combined detection of four serum tumor markers of AFP, AFU, CA199 and GP73 could effectively improve the positive rate of primary liver cancer, reduce missed diagnosis, and had high clinical value in judging tumor differentiation degree and prognosis, finding tumor recurrence and metastasis.
