中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
13期
2394-2397
,共4页
肺疾病,慢性阻塞性%内皮缩血管肽1%降钙素基因相关肽%肺气肿
肺疾病,慢性阻塞性%內皮縮血管肽1%降鈣素基因相關肽%肺氣腫
폐질병,만성조새성%내피축혈관태1%강개소기인상관태%폐기종
Pulmonary disease,chronic obstructive%Endothelin-1%Calcitonin gene-related peptide%Pulmonary emphysema
目的：探讨慢性阻塞性肺疾病患者血管内皮素-1（ET-1）与降钙素基因相关肽（CGRP）检测的临床价值。方法选取86例慢性阻塞性肺疾病患者作为观察组，50例同期健康志愿者为对照组，测定两组ET-1及CGRP水平，并结合慢性阻塞性肺疾病临床分级作比较分析。结果Ⅰ、Ⅱ、Ⅲ级慢性阻塞性肺疾病患者CGRP水平分别为（26.8±10.1）μg/L、（23.5±6.9）μg/L、（21.3±3.5）μg/L，均低于对照组，比较差异有统计学意义（P＜0.05）；Ⅲ级慢性阻塞性肺疾病患者ET-1水平为（90.2±6.3）μg/L，高于对照组及Ⅰ级慢性阻塞性肺疾病患者（P＜0.05）；Ⅱ级慢性阻塞性肺疾病患者ET-1水平为（74.6±5.5）μg/L，高于对照组及Ⅰ级慢性阻塞性肺疾病患者（P＜0.05）；相比于吸氧前，Ⅱ级及Ⅲ级慢性阻塞性肺疾病患者吸氧后CGRP水平[（17.5±5.8）μg/L 、（19.8±9.6）μg/L]明显升高，ET-1水平[（61.4±6.3）μg/L、（73.2±5.4）μg/L]明显降低（P＜0.05）。Spearman 相关分析显示慢性阻塞性肺疾病患者CGRP与ET-1间存在显著负相关（r＝-0.754，P＜0.05）。结论 ET-1及CGRP 水平是判断慢性阻塞性肺疾病患者病情的重要指标，缺氧可能通过影响CGRP 与ET-1间动态平衡导致慢性阻塞性肺疾病发生。
目的：探討慢性阻塞性肺疾病患者血管內皮素-1（ET-1）與降鈣素基因相關肽（CGRP）檢測的臨床價值。方法選取86例慢性阻塞性肺疾病患者作為觀察組，50例同期健康誌願者為對照組，測定兩組ET-1及CGRP水平，併結閤慢性阻塞性肺疾病臨床分級作比較分析。結果Ⅰ、Ⅱ、Ⅲ級慢性阻塞性肺疾病患者CGRP水平分彆為（26.8±10.1）μg/L、（23.5±6.9）μg/L、（21.3±3.5）μg/L，均低于對照組，比較差異有統計學意義（P＜0.05）；Ⅲ級慢性阻塞性肺疾病患者ET-1水平為（90.2±6.3）μg/L，高于對照組及Ⅰ級慢性阻塞性肺疾病患者（P＜0.05）；Ⅱ級慢性阻塞性肺疾病患者ET-1水平為（74.6±5.5）μg/L，高于對照組及Ⅰ級慢性阻塞性肺疾病患者（P＜0.05）；相比于吸氧前，Ⅱ級及Ⅲ級慢性阻塞性肺疾病患者吸氧後CGRP水平[（17.5±5.8）μg/L 、（19.8±9.6）μg/L]明顯升高，ET-1水平[（61.4±6.3）μg/L、（73.2±5.4）μg/L]明顯降低（P＜0.05）。Spearman 相關分析顯示慢性阻塞性肺疾病患者CGRP與ET-1間存在顯著負相關（r＝-0.754，P＜0.05）。結論 ET-1及CGRP 水平是判斷慢性阻塞性肺疾病患者病情的重要指標，缺氧可能通過影響CGRP 與ET-1間動態平衡導緻慢性阻塞性肺疾病髮生。
목적：탐토만성조새성폐질병환자혈관내피소-1（ET-1）여강개소기인상관태（CGRP）검측적림상개치。방법선취86례만성조새성폐질병환자작위관찰조，50례동기건강지원자위대조조，측정량조ET-1급CGRP수평，병결합만성조새성폐질병림상분급작비교분석。결과Ⅰ、Ⅱ、Ⅲ급만성조새성폐질병환자CGRP수평분별위（26.8±10.1）μg/L、（23.5±6.9）μg/L、（21.3±3.5）μg/L，균저우대조조，비교차이유통계학의의（P＜0.05）；Ⅲ급만성조새성폐질병환자ET-1수평위（90.2±6.3）μg/L，고우대조조급Ⅰ급만성조새성폐질병환자（P＜0.05）；Ⅱ급만성조새성폐질병환자ET-1수평위（74.6±5.5）μg/L，고우대조조급Ⅰ급만성조새성폐질병환자（P＜0.05）；상비우흡양전，Ⅱ급급Ⅲ급만성조새성폐질병환자흡양후CGRP수평[（17.5±5.8）μg/L 、（19.8±9.6）μg/L]명현승고，ET-1수평[（61.4±6.3）μg/L、（73.2±5.4）μg/L]명현강저（P＜0.05）。Spearman 상관분석현시만성조새성폐질병환자CGRP여ET-1간존재현저부상관（r＝-0.754，P＜0.05）。결론 ET-1급CGRP 수평시판단만성조새성폐질병환자병정적중요지표，결양가능통과영향CGRP 여ET-1간동태평형도치만성조새성폐질병발생。
ObjectiveTo study the chronic obstructive pulmonary disease(COPD) in patients with vascular endothelin-1 (ET-1) and calcitonin gene related peptide (CGRP) and clinical value of detection.Methods86 patients with COPD as the observation group, 50 healthy volunteers as control group, ET-1 and CGRP levels of two groups were detected, COPD clinical classification were comparative analyzed.ResultsⅠ,Ⅱ,ⅢCOPD patients, CGRP levels were (26.8±10.1)μg/L, (23.5±6.9)μg/L, (21.3±3.5)μg/L, were lower than the control group, with significant difference (P<0.05); The level of ET-1 in patients with gradeⅢCOPD was (90.2±6.3)μg/L, higher than that of the control group and grade COPD patients (P<0.05); The level of ET-1 in patients with classⅡCOPD (74.6±5.5)μg/L, higher than that of the control group and grade COPD patients (P<0.05); Comparedto the oxygen, CGRP level [(17.5±5.8)μg/L, (19.8±9.6)μg/L] ofⅡ andⅢ COPD patients after oxygen treatment increased significantly, the level of ET-1 [(61.4±6.3)μg/L, (73.2±5.4)μg/L] was significantly decreased(P<0.05). Spearman correlation analysis showed that there was significant negative correlation between ET-1 and COPD in patients with CGRP (r=-0.754,P<0.05).ConclusionET-1 and CGRP levels are important index to judge the condition of patients with COPD, hypoxia may lead to COPD occurs through the effect of dynamic balance of CGRP and ET-1.
