CAJ | 학술논문

目的：探讨血清降钙素原（PCT）与C-反应蛋白(CRP)联合检测在急诊脓毒症诊断中的应用。方法：将200例2012年1月至2014年1月期间我院收治的急诊患者根据病情分为轻度脓毒症组（n=43）、重度脓毒症组（n=25）和其他组（n=132），并选取同期健康者30例组成对照组。采用ELISA法检测患者血清PCT与CRP水平的变化并分析血清PCT与CRP对急诊脓毒症的预测作用。结果：轻度脓毒症组和、重度脓毒症组血清PCT与CRP水平均较其他组和对照组升高，重度脓毒症组PCT与CRP亦较轻度脓毒症组升高（P<0.05）。患者PCT与CRP水平均与脓毒症严重程度呈正相关（rPCT=7.453, rCRP=8.241,P<0.05）。Logistic回归分析结果显示，急诊脓毒症的危险因素有凝血功能紊乱、PCT与CRP水平升高等。结论：血清降钙素原和C-反应蛋白的测定值对急诊脓毒症诊断具有重要意义，可作为急诊脓毒症诊断指标。
목적：탐토혈청강개소원（PCT）여C-반응단백(CRP)연합검측재급진농독증진단중적응용。방법：장200례2012년1월지2014년1월기간아원수치적급진환자근거병정분위경도농독증조（n=43）、중도농독증조（n=25）화기타조（n=132），병선취동기건강자30례조성대조조。채용ELISA법검측환자혈청PCT여CRP수평적변화병분석혈청PCT여CRP대급진농독증적예측작용。결과：경도농독증조화、중도농독증조혈청PCT여CRP수평균교기타조화대조조승고，중도농독증조PCT여CRP역교경도농독증조승고（P<0.05）。환자PCT여CRP수평균여농독증엄중정도정정상관（rPCT=7.453, rCRP=8.241,P<0.05）。Logistic회귀분석결과현시，급진농독증적위험인소유응혈공능문란、PCT여CRP수평승고등。결론：혈청강개소원화C-반응단백적측정치대급진농독증진단구유중요의의，가작위급진농독증진단지표。
Objective:To investigate the application of the combined determination of serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of emergency sepsis.Methods:Two hundred cases of emergency patients who were treated in our hospital from January 2012 to January 2014 were divided into a mild sepsis group (n=43), a severe sepsis group (n=25) and the other group (n=132), and 30 healthy subjects were selected as a control group. ELISA method was used to detect the change of serum PCT and CRP levels in patients and the values of serum PCT and CRP were used for predicting their relationship with emergency sepsis.Results:Serum PCT and CRP levels in the mild sepsis and severe sepsis groups were higher than those in other group and the control group, and PCT and CRP levels in severe sepsis group were higher than those in the mild sepsis group (P<0.05). PCT and CRP levels were positively correlated with sepsis severity (rPCT=7.453, rCRP=7.453, P<0.05). Logistic regression analysis showed that risk factors of emergency sepsis appeared as blood coagulation dysfunction and the enhanced levels of PCT and CRP.Conclusion:The determination values of serum procalcitonin and C-reactive protein levels are of signiifcance in the diagnosis of emergency sepsis, which can be used as indicators for the diagnosis of emergency sepsis .