CAJ | 학술논문

目的：探讨盐酸右美托咪定在宫颈癌根治术中的镇静效果。方法：将64例宫颈癌患者按随机数表法分为A和B组，每组32例。两组患者均使用盐酸瑞芬太尼进行麻醉，其中A组患者在麻醉过程中加用盐酸右美托咪定[起始6μg/kg，15 min后为0.1μg/（kg·h）]，B组患者在麻醉过程中加用丙泊酚（起始6μg/kg，15 min后根据手术情况调整用量）。比较两组患者的镇静和镇痛效果、不良反应以及医生和患者的满意度。结果：A组Ramsay镇静评分在2~4分和《重症疼痛观察工具》评分在0~4分的患者比例均高于B组，差异有统计学意义。A组患者的各不良反应发生率均低于B组，患者和医生的满意度也高于B组，差异都有统计学意义。结论：在宫颈癌根治术中加用盐酸右美托咪定可增强镇静效果、减少不良反应的发生、提高医生和患者的满意度，值得进行进一步的临床研究。
목적：탐토염산우미탁미정재궁경암근치술중적진정효과。방법：장64례궁경암환자안수궤수표법분위A화B조，매조32례。량조환자균사용염산서분태니진행마취，기중A조환자재마취과정중가용염산우미탁미정[기시6μg/kg，15 min후위0.1μg/（kg·h）]，B조환자재마취과정중가용병박분（기시6μg/kg，15 min후근거수술정황조정용량）。비교량조환자적진정화진통효과、불량반응이급의생화환자적만의도。결과：A조Ramsay진정평분재2~4분화《중증동통관찰공구》평분재0~4분적환자비례균고우B조，차이유통계학의의。A조환자적각불량반응발생솔균저우B조，환자화의생적만의도야고우B조，차이도유통계학의의。결론：재궁경암근치술중가용염산우미탁미정가증강진정효과、감소불량반응적발생、제고의생화환자적만의도，치득진행진일보적림상연구。
Objective: To investigate the sedative effects of dexmedetomidine hydrochloride in the operation of radical hysterectomy.Methods: Sixty-four patients with cervical cancer were divided into group A or B with 32 cases each by digital randomized method. Remifentanil hydrochloride was given in two groups, and in addition, dexmedetomidine hydrochloride (starting at 6mg/kg and then 0.1 μg/(kg·h) after 15 min) was given in group A and propofol (starting at 6mg/kg, 15 min later the dosage was adjusted according to operation condition) in group B during anesthesia. Sedation and analgesia effect, adverse reaction and the satisfaction of doctors and patients were compared between two groups.Results: The ratio of patients with Ramsay sedation scores 2~4 points and Severe Pain Observation Tools score 0~4 was higher in group A than in group B, the satisfaction rate of doctor and patient was also higher in group A than in group B, and the incidence of adverse reactions was lower in group A than in group B. All the differences are statistically signiifcant.Conclusion: Additional use of dexmedetomidine hydrochloride in the operation of radical hysterectomy is worthy of further clinical study since it can enhance the sedative effect, reduce the occurrence of adverse reactions and improve the satisfaction of doctors and patients.