CAJ | 학술논문

目的：探讨首发抑郁症患者敏感脑结构在多种磁共振序列下的表现，并研究多种磁共振序列成像联合检测诊断首发抑郁症的价值。方法分别采用快速自旋回波三维序列（FLASH3d）、多体素（MVS）磁共振波谱检测序列（3D鄄CSI）及磁敏感加权序列（SWI）对20例首发抑郁症患者（观察组）和20例健康志愿者（对照组）的双侧海马进行体积形态成像、磁共振波谱检测及引流静脉成像。结果与对照组比较，观察组患者双侧海马体积明显缩小，差异有统计学意义（P<0.05）；双侧海马谷氨酸盐混合物（Glx）/肌酸（Cr）及乙酰天门冬氨酸盐（NAA）/Cr降低，胆碱（Cho）/Cr升高，差异有统计学意义（P<0.05）；肌醇（MI）/Cr变化不明显。双侧脑室下静脉最大直径（D）、长度（L）及分支数目（N）均减少，差异均有统计学意义（P<0.05）。结论首发抑郁症患者敏感脑区经多种磁共振序列检测均产生了变化，联合多种磁共振序列检测能更好地筛选出首发抑郁症患者，为临床防治提供了客观依据及帮助。
목적：탐토수발억욱증환자민감뇌결구재다충자공진서렬하적표현，병연구다충자공진서렬성상연합검측진단수발억욱증적개치。방법분별채용쾌속자선회파삼유서렬（FLASH3d）、다체소（MVS）자공진파보검측서렬（3D견CSI）급자민감가권서렬（SWI）대20례수발억욱증환자（관찰조）화20례건강지원자（대조조）적쌍측해마진행체적형태성상、자공진파보검측급인류정맥성상。결과여대조조비교，관찰조환자쌍측해마체적명현축소，차이유통계학의의（P<0.05）；쌍측해마곡안산염혼합물（Glx）/기산（Cr）급을선천문동안산염（NAA）/Cr강저，담감（Cho）/Cr승고，차이유통계학의의（P<0.05）；기순（MI）/Cr변화불명현。쌍측뇌실하정맥최대직경（D）、장도（L）급분지수목（N）균감소，차이균유통계학의의（P<0.05）。결론수발억욱증환자민감뇌구경다충자공진서렬검측균산생료변화，연합다충자공진서렬검측능경호지사선출수발억욱증환자，위림상방치제공료객관의거급방조。
Objective To explore the brain manifestation of the first episode depression under multi-magnetic resonance (MR) sequence image,and research the diagnostic value of multi-MR sequence image on the first episode depression. Methods The FLASH3d,(MVS)3D-CSI and susceptibility weighted imaging(SWI) sequence were adopted to detect the volume morpho-logical imaging of bilateral hippocampus ,magnetic resonance spectrum and draining vein imaging on 20 patients with first episode depression(observation group) and 20 healthy volunteers(control group). Results Compared with the control group,the volume of the bilateral hippocampus in the observation group was reduced obviously with statistically significant difference (P<0.05);the values of Glx/Cr and NAA/Cr in bilateral hippocampus were reduced ,the value of Cho/Cr was increased ,and the differences between the two groups had statistical significance(P<0.05);the changes of MI/Cr were not unobvious;the maximum diameter(D), length(L) and the branching number of the inferior ventricular vein were all reduced,and the difference between the two group was statistically significant(P<0.05). Conclusion The sensitive encephalic region of the first episode depression has been changed after detection of multi-MR sequence image,the combination of multi-MR sequence detection can sieve the first episode depres-sion better and provide the evidence and assistance for clinical prevention.