中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
19期
10-11,12
,共3页
食管癌%P53蛋白%Ki67
食管癌%P53蛋白%Ki67
식관암%P53단백%Ki67
Esophageal cancer%P53 protein%Ki67
目的：研究P53蛋白、Ki67在食管癌中的表达，探讨其临床意义。方法采用免疫组化法检测35例食管癌，13例食管炎组织中P53蛋白和Ki67的表达水平，分析其与临床及病理各参数的相关性。结果 P53蛋白、Ki67在食管癌组织中的阳性表达率显著高于食管炎，差异均有统计学意义（P=0.046，P=0.001）。在食管癌组织中P53蛋白的阳性表达率在临床分期、浸润程度、淋巴结转移及组织学分化程度方面有明显差异（P<0.05），Ki67的阳性表达率仅与食管癌的临床分期和浸润深度有关（P<0.05），与组织学分化程度和淋巴结转移无关（P>0.05）。食管癌组织中P53蛋白和Ki67的表达密切相关（P=0.006）。结论 P53蛋白和Ki67与食管癌的发生、发展有关，二者协作检测对判断食管癌恶性程度和预后具有重要的临床意义。
目的：研究P53蛋白、Ki67在食管癌中的錶達，探討其臨床意義。方法採用免疫組化法檢測35例食管癌，13例食管炎組織中P53蛋白和Ki67的錶達水平，分析其與臨床及病理各參數的相關性。結果 P53蛋白、Ki67在食管癌組織中的暘性錶達率顯著高于食管炎，差異均有統計學意義（P=0.046，P=0.001）。在食管癌組織中P53蛋白的暘性錶達率在臨床分期、浸潤程度、淋巴結轉移及組織學分化程度方麵有明顯差異（P<0.05），Ki67的暘性錶達率僅與食管癌的臨床分期和浸潤深度有關（P<0.05），與組織學分化程度和淋巴結轉移無關（P>0.05）。食管癌組織中P53蛋白和Ki67的錶達密切相關（P=0.006）。結論 P53蛋白和Ki67與食管癌的髮生、髮展有關，二者協作檢測對判斷食管癌噁性程度和預後具有重要的臨床意義。
목적：연구P53단백、Ki67재식관암중적표체，탐토기림상의의。방법채용면역조화법검측35례식관암，13례식관염조직중P53단백화Ki67적표체수평，분석기여림상급병리각삼수적상관성。결과 P53단백、Ki67재식관암조직중적양성표체솔현저고우식관염，차이균유통계학의의（P=0.046，P=0.001）。재식관암조직중P53단백적양성표체솔재림상분기、침윤정도、림파결전이급조직학분화정도방면유명현차이（P<0.05），Ki67적양성표체솔부여식관암적림상분기화침윤심도유관（P<0.05），여조직학분화정도화림파결전이무관（P>0.05）。식관암조직중P53단백화Ki67적표체밀절상관（P=0.006）。결론 P53단백화Ki67여식관암적발생、발전유관，이자협작검측대판단식관암악성정도화예후구유중요적림상의의。
Objective To investigate the expression of protein P53 and Ki67 in esophageal cancer and analyze its clinical significance. Methods The expression of P53 and Ki67 in esophageal cancer of 35 cases and esophagitis of 13 cases were detected through immunohistochemistry, respectively. The relationship between theirs clinical and pathological parameters was analyzed. Results The expression rate of protein P53 and Ki67 in 35 cases of esophageal cancer were significantly higher than that in esophagitis, the difference was statistically significant among two groups (P=0.046, P=0.001). In esophageal cancer, the results showed that there was significant difference of expression of protein P53 between the depth of invasion, lymph node metastasis, clinical staging and the degree of differentiation(P<0.05). While the expression of Ki67 was only significantly associated with the depth of invasion (P=0.042) and clinical staging (P=0.025). But it was not associated with the degree of differentiation and lymph node metastasis (P>0.05). The positive expression of protein P53 and Ki6 were closely related(P=0.006). Conclution The expression of P53 and Ki67 were associated with the occurrence and development of esophageal cancer. Therefore, The two joint detection had important clinical value to predict the degree of malignancy and prognosis of esophageal cancer.
