中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
19期
86-89
,共4页
生脉注射液%感染性休克%效果
生脈註射液%感染性休剋%效果
생맥주사액%감염성휴극%효과
Shengmai Injection%Septic shock%Curative effect
目的：观察生脉注射液治疗感染性休克的临床效果。方法选取2011年10月~2013年12月重庆市忠县中医院收治的感染性休克患者68例为研究对象,将所有患者按照随机数字表法分成观察组和对照组,各34例。对照组给予常规治疗方法,观察组在对照组治疗的基础上加用生脉注射液60 mL加入5%葡萄糖注射液或0.9%氯化钠注射液250~500 mL,静脉滴注,每日1次,连用7 d。观察指标院临床疗效,两组治疗前后血清C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子α(TNF-α)水平,生命体征复常时间,不良反应发生情况。结果观察组总有效率(97.06%)明显高于对照组(79.41%),差异有统计学意义(P<0.05)。观察组及对照组治疗后CRP、PCT及TNF-α水平[(4.32±1.05)mg/L,(0.93±0.06)滋g/L,(76.22±14.33)ng/L；(6.83±2.39)mg/L,(2.67±0.83)滋g/L,(100.36±21.58)ng/L]均较治疗前显著下降(均P<0.05),且观察组治疗后较对照组降低更显著(P<0.05)。观察组呼吸、心率、血压复常时间[(2.56±0.84)、(2.34±0.55)、(1.65±0.43)h]均显著少于对照组[(4.04±1.22)、(4.98±1.67)、(2.03±0.95)h],差异均有统计学意义(均P<0.05)。观察组在治疗过程中仅出现1例腹胀,停药后消失,余未见其他明显不良反应。结论生脉注射液治疗感染性休克临床效果好,能明显改善患者血清CRP、PCT及TNF-α水平,还可以缩短生命体征复常时间,且不良反应少,值得临床推广应用。
目的：觀察生脈註射液治療感染性休剋的臨床效果。方法選取2011年10月~2013年12月重慶市忠縣中醫院收治的感染性休剋患者68例為研究對象,將所有患者按照隨機數字錶法分成觀察組和對照組,各34例。對照組給予常規治療方法,觀察組在對照組治療的基礎上加用生脈註射液60 mL加入5%葡萄糖註射液或0.9%氯化鈉註射液250~500 mL,靜脈滴註,每日1次,連用7 d。觀察指標院臨床療效,兩組治療前後血清C反應蛋白(CRP)、降鈣素原(PCT)、腫瘤壞死因子α(TNF-α)水平,生命體徵複常時間,不良反應髮生情況。結果觀察組總有效率(97.06%)明顯高于對照組(79.41%),差異有統計學意義(P<0.05)。觀察組及對照組治療後CRP、PCT及TNF-α水平[(4.32±1.05)mg/L,(0.93±0.06)滋g/L,(76.22±14.33)ng/L；(6.83±2.39)mg/L,(2.67±0.83)滋g/L,(100.36±21.58)ng/L]均較治療前顯著下降(均P<0.05),且觀察組治療後較對照組降低更顯著(P<0.05)。觀察組呼吸、心率、血壓複常時間[(2.56±0.84)、(2.34±0.55)、(1.65±0.43)h]均顯著少于對照組[(4.04±1.22)、(4.98±1.67)、(2.03±0.95)h],差異均有統計學意義(均P<0.05)。觀察組在治療過程中僅齣現1例腹脹,停藥後消失,餘未見其他明顯不良反應。結論生脈註射液治療感染性休剋臨床效果好,能明顯改善患者血清CRP、PCT及TNF-α水平,還可以縮短生命體徵複常時間,且不良反應少,值得臨床推廣應用。
목적：관찰생맥주사액치료감염성휴극적림상효과。방법선취2011년10월~2013년12월중경시충현중의원수치적감염성휴극환자68례위연구대상,장소유환자안조수궤수자표법분성관찰조화대조조,각34례。대조조급여상규치료방법,관찰조재대조조치료적기출상가용생맥주사액60 mL가입5%포도당주사액혹0.9%록화납주사액250~500 mL,정맥적주,매일1차,련용7 d。관찰지표원림상료효,량조치료전후혈청C반응단백(CRP)、강개소원(PCT)、종류배사인자α(TNF-α)수평,생명체정복상시간,불량반응발생정황。결과관찰조총유효솔(97.06%)명현고우대조조(79.41%),차이유통계학의의(P<0.05)。관찰조급대조조치료후CRP、PCT급TNF-α수평[(4.32±1.05)mg/L,(0.93±0.06)자g/L,(76.22±14.33)ng/L；(6.83±2.39)mg/L,(2.67±0.83)자g/L,(100.36±21.58)ng/L]균교치료전현저하강(균P<0.05),차관찰조치료후교대조조강저경현저(P<0.05)。관찰조호흡、심솔、혈압복상시간[(2.56±0.84)、(2.34±0.55)、(1.65±0.43)h]균현저소우대조조[(4.04±1.22)、(4.98±1.67)、(2.03±0.95)h],차이균유통계학의의(균P<0.05)。관찰조재치료과정중부출현1례복창,정약후소실,여미견기타명현불량반응。결론생맥주사액치료감염성휴극림상효과호,능명현개선환자혈청CRP、PCT급TNF-α수평,환가이축단생명체정복상시간,차불량반응소,치득림상추엄응용。
Objective To observe the curative effect of Shengmai Injection in the treatment of septic shock. Methods 68 cases with septic shock admitted to Zhong County Hospital of Traditional Chinese Medicine from October 2011 to December 2013 were chosen as objects. All patients were divided into observation group and control group by random number table, with 34 cases in each group. The control group was given conventional treatment method, while observa-tion group was added with Shengmai Injection 60 mL into 250-500 mL of 5% Glucose Injection or 0.9% Sodium Chlo-ride Injection on basis of control group, iv gtt, once a day, for 7 days. The observational index: clinical effect; the level of CRP, PCT, TNF-αbefore and after treatment between the two groups;the time of vital signs return to normal;condi-tions of adverse reactions. Results The total effective rate of observation group (97.06%) was higher than that of control group (79.41%), the difference was statistically significant (P< 0.05). The levels of CRP, PCT, TNF-α after treatment in the observation group and control group [(4.32±1.05) mg/L, (0.93±0.06) μg/L, (76.22±14.33) ng/L; (6.83±2.39) mg/L, (2.67±0.83) μg/L, (100.36±21.58) ng/L] were decreased significantly compared with before treatment (P< 0.05), more-over, observation group was decreased more obviously than control group (P<0.05). The time of respiration, heart rate, blood pressure return to normal in observation group [(2.56±0.84), (2.34±0.55), (1.65±0.43) h] was significantly less than that of control group [(4.04±1.22), (4.98±1.67), (2.03±0.95) h] (P< 0.05). There was 1 case of abdominal disten-tion during the treatment, which was disappeared after stopping drugs, the others had no obvious adverse reactions. Conclusion Shengmai Injection in the treatment of septic shock has a good clinical effect, which can significantly im-prove the level of CRP, PCT, TNF-α, shorten the time of vital signs return to normal, and the adverse reactions are less, which is worthy of clinical promotion and application.
