中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
19期
35-38
,共4页
原发性肾病综合征%尿蛋白%儿童
原髮性腎病綜閤徵%尿蛋白%兒童
원발성신병종합정%뇨단백%인동
PNS%Proteinuria%Children
目的：分析儿童原发性肾病综合征激素治疗后尿蛋白转阴时间的影响因素。方法146例原发性肾病综合征患儿行激素治疗后,可评价疗效136例。按照尿蛋白转阴时间分为A组(尿蛋白转阴时间≤1周)和B组(1周<尿蛋白转阴时间≤2周)。其中A组男44例,女4例；B组男74例,女14例。对患儿各种常规情况、生化指标行单因素分析及多因素Logistic回归分析。结果单因素分析显示,父母认知情况、水肿程度、水肿至口服激素时间、是否存在合并感染、入院时血浆IgM水平、血浆白蛋白水平、胶体渗透压等指标在A、B组间差异有统计学意义(P<0.05)。多因素Logistic回归分析提示院父母认知情况差(P=0.004,OR=0.087)、水肿至口服激素时间长(P=0.000,OR=20.676)、胶体渗透压低(P=0.025,OR=0.649)与尿蛋白转阴时间有关。结论父母认知情况差、水肿至口服激素时间长、胶体渗透压低为原发性肾病综合征患儿尿蛋白转阴时间>1周的危险因素,与患儿的不良预后相关,临床应予以高度重视。
目的：分析兒童原髮性腎病綜閤徵激素治療後尿蛋白轉陰時間的影響因素。方法146例原髮性腎病綜閤徵患兒行激素治療後,可評價療效136例。按照尿蛋白轉陰時間分為A組(尿蛋白轉陰時間≤1週)和B組(1週<尿蛋白轉陰時間≤2週)。其中A組男44例,女4例；B組男74例,女14例。對患兒各種常規情況、生化指標行單因素分析及多因素Logistic迴歸分析。結果單因素分析顯示,父母認知情況、水腫程度、水腫至口服激素時間、是否存在閤併感染、入院時血漿IgM水平、血漿白蛋白水平、膠體滲透壓等指標在A、B組間差異有統計學意義(P<0.05)。多因素Logistic迴歸分析提示院父母認知情況差(P=0.004,OR=0.087)、水腫至口服激素時間長(P=0.000,OR=20.676)、膠體滲透壓低(P=0.025,OR=0.649)與尿蛋白轉陰時間有關。結論父母認知情況差、水腫至口服激素時間長、膠體滲透壓低為原髮性腎病綜閤徵患兒尿蛋白轉陰時間>1週的危險因素,與患兒的不良預後相關,臨床應予以高度重視。
목적：분석인동원발성신병종합정격소치료후뇨단백전음시간적영향인소。방법146례원발성신병종합정환인행격소치료후,가평개료효136례。안조뇨단백전음시간분위A조(뇨단백전음시간≤1주)화B조(1주<뇨단백전음시간≤2주)。기중A조남44례,녀4례；B조남74례,녀14례。대환인각충상규정황、생화지표행단인소분석급다인소Logistic회귀분석。결과단인소분석현시,부모인지정황、수종정도、수종지구복격소시간、시부존재합병감염、입원시혈장IgM수평、혈장백단백수평、효체삼투압등지표재A、B조간차이유통계학의의(P<0.05)。다인소Logistic회귀분석제시원부모인지정황차(P=0.004,OR=0.087)、수종지구복격소시간장(P=0.000,OR=20.676)、효체삼투압저(P=0.025,OR=0.649)여뇨단백전음시간유관。결론부모인지정황차、수종지구복격소시간장、효체삼투압저위원발성신병종합정환인뇨단백전음시간>1주적위험인소,여환인적불량예후상관,림상응여이고도중시。
Objective To analyze the influencing factors of proteinuria elimination time after hormone therapy in chil-dren with primary nephrotic syndrome (PNS). Methods 146 cases of children with PNS were treated by hormone, and a-mong them 136 patients were evaluated for efficacy and tolerability. The patients were divided into two groups accord-ing to proteinuria elimination time. The proteinuria elimination time≤1 week of patients were in group A, while 1 week< proteinuria elimination time ≤2 weeks of patients were in group B. There were 44 male and 4 female in group A, and 74 male and 14 female in group B respectively .Children's characteristics and laboratory indicators were collected, and then the univariate analysis and multiple-factor Logistic regression analysis were performed. Results Univariate analysis showed that indicators of awareness of parents, degree of swelling, time from edema to oral hormone, with or without infection, plasma IgM level, level of albumin, colloid osmotic pressure were significant differences between group A and group B (P<0.05). Multiple-factor Logistic regression analysis showed that poor awareness level of par-ents (P=0.004, OR=0.087), long time from edema to oral hormone (P=0.000, OR=20.676), low plasma colloid osmotic pressure (P=0.025, OR=0.649) were related to proteinuria elimination time. Conclusion Poor awareness level of par-ents, long time from edema to oral hormone, low plasma colloid osmotic pressure are the risk factors of proteinuria elim-ination time > 1 week in children with PNS, which also relate to the worse prognosis and need to be paid more atten-tion in clinic.
