CAJ | 학술논문

目的：观察血浆同型半胱氨酸浓度与冠心病有无相关性，探讨同型半胱氨酸在冠心病发病机制中的作用。方法238例在我院住院并且行冠状动脉造影的患者同期测定血浆同型半胱氨酸的浓度，根据造影结果及临床资料分为4组，非冠心病组、稳定型心绞痛、不稳定型心绞痛、心肌梗死组。分析同型半胱氨酸浓度在上述人群中有无差别并探讨其意义。结果同型半胱氨酸浓度在非冠心病组和冠心病组（包括稳定型心绞痛、不稳定型心绞痛、急性心肌梗死）差异有统计学意义（P＜0.05）。进一步亚组分析表明，急性心肌梗死的患者血浆同型半胱氨酸的浓度和不稳定型心绞痛、稳定型心绞痛相比，差异有统计学意义（P＜0.05）。与非冠心病组相比具有显著的统计学差异（P＜0.01)。结论同型半胱氨酸在冠心病的发病中有重要作用，特别是在急性心肌梗死中显得尤为显著。
목적：관찰혈장동형반광안산농도여관심병유무상관성，탐토동형반광안산재관심병발병궤제중적작용。방법238례재아원주원병차행관상동맥조영적환자동기측정혈장동형반광안산적농도，근거조영결과급림상자료분위4조，비관심병조、은정형심교통、불은정형심교통、심기경사조。분석동형반광안산농도재상술인군중유무차별병탐토기의의。결과동형반광안산농도재비관심병조화관심병조（포괄은정형심교통、불은정형심교통、급성심기경사）차이유통계학의의（P＜0.05）。진일보아조분석표명，급성심기경사적환자혈장동형반광안산적농도화불은정형심교통、은정형심교통상비，차이유통계학의의（P＜0.05）。여비관심병조상비구유현저적통계학차이（P＜0.01)。결론동형반광안산재관심병적발병중유중요작용，특별시재급성심기경사중현득우위현저。
Objective In order to observe weather the plasma homocysteine concentration and coronary heart disease (CHD) are correlated and discussed the role of homocysteine in the pathogenesis of coronary heart disease. Methods 238 cases hospitalized in our hospital and line of coronary angiography, at the same time ,the patients with the determination of plasma homocysteine concentration, according to the results of imaging and clinical data the patients is divided into four groups, the CHD group, stable angina, unstable angina and myocardial infarction group. Analysis of homocysteine concentrations in the crowd weather there is difference and to discuss its significance. Results The results of the plasma homocysteine concentration in non-coronary heart disease and coronary heart disease group (including stable angina, unstable angina and acute myocardial infarction) difference was statistically significant (P<0.05). Further subgroup analysis showed that patients with acute myocardial infarction (MI) of plasma homocysteine concentration compared with stable angina and unstable angina, the difference was statistically significant (P<0.05). Compared with non CHD group, it is significant statistical difference (P<0.01). Conclusion Homocysteine play an important role in the pathogenesis of coronary heart disease, especially in acute myocardial infarction (MI) is especially significant.